Natural intramolecular isotope measurements in physiology: elements of the case for an effort toward high-precision position-specific isotope analysis

• Published in: Rapid communications in mass spectrometry Vol. 15; no. 15; pp. 1252 - 1262
• Main Author: Brenna, J. T.
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 15.08.2001
• Subjects: Acetates - metabolism; Amino Acids - biosynthesis; Amino Acids - chemistry; Amino Acids - physiology; Animals; Biomarkers; Brain - physiology; Carbon Isotopes - analysis; Chickens; Diet; DNA - chemistry; DNA - physiology; Fatty Acids - metabolism; Female; Genomics; Glucose - metabolism; Glycerol - metabolism; Humans; Isotopes - analysis; Macromolecular Substances; Male; Mass Spectrometry - instrumentation; Mass Spectrometry - methods; Molecular Conformation; Molecular Structure; Nerve Tissue - physiology; Pregnancy; Proteome - physiology; Purines - metabolism; Rats; Species Specificity

Chemical information available in organisms can be categorized into three major domains, macromolecular, small molecules, and isotope ratios. Information about physiological state is commonly obtained by qualitative and quantitative analysis in the macromolecular and small molecule domains. Genomics...