Multiphoton microscope measurement–based biphasic multiscale analyses of knee joint articular cartilage and chondrocyte by using visco‐anisotropic hyperelastic finite element method and smoothed particle hydrodynamics method

• Published in: International journal for numerical methods in biomedical engineering Vol. 33; no. 11
• Main Authors: Nakamachi, Eiji, Noma, Tomohiro, Nakahara, Kaito, Tomita, Yoshihiro, Morita, Yusuke
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.11.2017
• Subjects: Anisotropy; articular cartilage; Biomechanical Phenomena; Bioreactors; biphasic multiscale analysis; Cartilage; Cartilage (articular); Cartilage, Articular - anatomy & histology; Cartilage, Articular - physiology; chondrocyte; Chondrocytes; Chondrocytes - cytology; Collagen; Computational fluid dynamics; Elasticity; Fiber orientation; Finite Element Analysis; Finite element method; Fluid flow; Fluid mechanics; Humans; Hydrodynamics; hyperelastic constitutive law; Iron; Knee; Knee Joint - anatomy & histology; Knee Joint - physiology; Lubrication; Mathematical analysis; Mathematical models; Medical treatment; Metabolism; Microscopy - methods; Models, Biological; Multiscale analysis; Regeneration; Rigidity; Smooth particle hydrodynamics; smoothed particle hydrodynamics method; Stress; Stress, Mechanical; Stress-strain relationships; Stresses; Tissues; Viscous flow; Viscous fluids; Walking; articular cartilage; chondrocyte; finite element method; smoothed particle hydrodynamics method; biphasic multiscale analysis; hyperelastic constitutive law

The articular cartilage of a knee joint has a variety of functions including dispersing stress and absorbing shock in the tissue and lubricating the surface region of cartilage. The metabolic activity of chondrocytes under the cyclic mechanical stimulations regenerates the morphology and function of...