Relaxation of human coronary artery and arteria mammaria by K(+)-channel openers

Three agents with K(+)-channel-opening activity--nicorandil, bimakalim (EMD 52692), and EMD 56431--were tested for vasorelaxation abilities in human coronary artery and human arteria mammaria. The potency orders were bimakalim = EMD 56431 >> nicorandil for relaxation in human coronary artery a...

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Published inJournal of cardiovascular pharmacology Vol. 20 Suppl 3; p. S13
Main Authors Bossaller, C, Auch-Schwelk, W, Graf, K, Gräfe, M, Catadelgirmen, G, Ennker, J, Fleck, E
Format Journal Article
LanguageEnglish
Published United States 1992
Subjects
Benzopyrans - pharmacology
Coronary Vessels - drug effects
Dihydropyridines - pharmacology
Humans
In Vitro Techniques
Mammary Arteries - drug effects
Niacinamide - analogs & derivatives
Niacinamide - pharmacology
Nicorandil
Potassium Channels - drug effects
Vasodilation - drug effects
Vasodilator Agents - pharmacology
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Abstract Three agents with K(+)-channel-opening activity--nicorandil, bimakalim (EMD 52692), and EMD 56431--were tested for vasorelaxation abilities in human coronary artery and human arteria mammaria. The potency orders were bimakalim = EMD 56431 >> nicorandil for relaxation in human coronary artery and bimakalim = EMD 56431 >> nicorandil in human arteria mammaria. These data demonstrate that K(+)-channel openers are effective vasorelaxant agents in human coronary artery and human arteria mammaria. Bimakalim and EMD 56431 were more potent than nicorandil, a drug that also activates guanylate cyclase.
AbstractList Three agents with K(+)-channel-opening activity--nicorandil, bimakalim (EMD 52692), and EMD 56431--were tested for vasorelaxation abilities in human coronary artery and human arteria mammaria. The potency orders were bimakalim = EMD 56431 >> nicorandil for relaxation in human coronary artery and bimakalim = EMD 56431 >> nicorandil in human arteria mammaria. These data demonstrate that K(+)-channel openers are effective vasorelaxant agents in human coronary artery and human arteria mammaria. Bimakalim and EMD 56431 were more potent than nicorandil, a drug that also activates guanylate cyclase.
Author Catadelgirmen, G
Auch-Schwelk, W
Gräfe, M
Ennker, J
Fleck, E
Bossaller, C
Graf, K
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Snippet Three agents with K(+)-channel-opening activity--nicorandil, bimakalim (EMD 52692), and EMD 56431--were tested for vasorelaxation abilities in human coronary...
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StartPage S13
SubjectTerms Benzopyrans - pharmacology
Coronary Vessels - drug effects
Dihydropyridines - pharmacology
Humans
In Vitro Techniques
Mammary Arteries - drug effects
Niacinamide - analogs & derivatives
Niacinamide - pharmacology
Nicorandil
Potassium Channels - drug effects
Vasodilation - drug effects
Vasodilator Agents - pharmacology
Title Relaxation of human coronary artery and arteria mammaria by K(+)-channel openers
URI https://www.ncbi.nlm.nih.gov/pubmed/1282170
Volume 20 Suppl 3
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