Relaxation of human coronary artery and arteria mammaria by K(+)-channel openers

Three agents with K(+)-channel-opening activity--nicorandil, bimakalim (EMD 52692), and EMD 56431--were tested for vasorelaxation abilities in human coronary artery and human arteria mammaria. The potency orders were bimakalim = EMD 56431 >> nicorandil for relaxation in human coronary artery a...

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Published inJournal of cardiovascular pharmacology Vol. 20 Suppl 3; p. S13
Main Authors Bossaller, C, Auch-Schwelk, W, Graf, K, Gräfe, M, Catadelgirmen, G, Ennker, J, Fleck, E
Format Journal Article
LanguageEnglish
Published United States 1992
Subjects
Benzopyrans - pharmacology
Coronary Vessels - drug effects
Dihydropyridines - pharmacology
Humans
In Vitro Techniques
Mammary Arteries - drug effects
Niacinamide - analogs & derivatives
Niacinamide - pharmacology
Nicorandil
Potassium Channels - drug effects
Vasodilation - drug effects
Vasodilator Agents - pharmacology
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Summary:Three agents with K(+)-channel-opening activity--nicorandil, bimakalim (EMD 52692), and EMD 56431--were tested for vasorelaxation abilities in human coronary artery and human arteria mammaria. The potency orders were bimakalim = EMD 56431 >> nicorandil for relaxation in human coronary artery and bimakalim = EMD 56431 >> nicorandil in human arteria mammaria. These data demonstrate that K(+)-channel openers are effective vasorelaxant agents in human coronary artery and human arteria mammaria. Bimakalim and EMD 56431 were more potent than nicorandil, a drug that also activates guanylate cyclase.
ISSN:0160-2446
1533-4023
DOI:10.1097/00005344-199206203-00004