Betaine postpones hyperglycemia‐related senescence in ovarian and testicular cells: Involvement of RAGE and β‐galactosidase

• Published in: Cell biochemistry and function Vol. 42; no. 2; pp. e3973 - n/a
• Main Authors: Mohammadi, Neda, Hemmati, Mina, Motlagh, Behrouz, Biyabani, Arezou
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.03.2024
• Subjects: Aging; Antioxidants; Betaine; Catalase; Diabetes mellitus; Down-regulation; Germ cells; Glutathione; Glutathione peroxidase; Glycine; Granulosa cells; Hyperglycemia; Infertility; Inflammation; Leydig cells; Ovaries; Oxidative stress; Peroxidase; Pyruvaldehyde; Reproductive system; Senescence; Structure-function relationships; Superoxide dismutase; Testes; hyperglycemia; aging; betaine; infertility; oxidative stress

The structural and functional disorders of the testis and ovary are one of the main complications of hyperglycemia. Betaine is a trimethyl glycine with antioxidant, antidiabetic, and anti‐inflammatory potential. The aim of this study is to investigate the potential of betaine on the expression of ag...