The role of Shh signalling pathway in central nervous system development and related diseases

Sonic hedgehog (Shh) plays important roles in developmental of vertebrate animal central nervous system (CNS), and Gli is its downstream signal molecule. Shh signalling is essential for pattern formation, cell‐fate specification, axon guidance, proliferation, survival and differentiation of neurons...

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Published inCell biochemistry and function Vol. 39; no. 2; pp. 180 - 189
Main Authors Li, Xiaoying, Li, Yunxiao, Li, Shuanqing, Li, Han, Yang, Ciqing, Lin, Juntang
Format Journal Article
LanguageEnglish
Published England Wiley Subscription Services, Inc 01.03.2021
Subjects
Autism
Axon guidance
Brain
Brain cancer
Brain research
Brain tumors
Cell differentiation
Central nervous system
Differentiation (biology)
Epilepsy
Head injuries
Hedgehog protein
Movement disorders
Nervous system
Nervous system diseases
Neurodegenerative diseases
Parkinson's disease
Pattern formation
Signal classification
Signal transduction
Signaling
signalling pathway
Sonic hedgehog
Spinal cord
Traumatic brain injury
Tumors
Vertebrates
Sonic hedgehog
spinal cord
signalling pathway
brain
central nervous system
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Abstract Sonic hedgehog (Shh) plays important roles in developmental of vertebrate animal central nervous system (CNS), and Gli is its downstream signal molecule. Shh signalling is essential for pattern formation, cell‐fate specification, axon guidance, proliferation, survival and differentiation of neurons in CNS development. The abnormal signalling pathway of Shh leads to the occurrence of many nervous system diseases. The mechanism of Shh signalling is complex and remains incompletely understood. Nevertheless, studies have revealed that Shh signalling pathway is classified into canonical and non‐canonical pathways. Here we review the role of the Shh signalling pathway and its impact in CNS development and related diseases. Specifically, we discuss the role of Shh in the spinal cord and brain development, cell differentiation and proliferation in CNS and related diseases such as brain tumour, Parkinson's diseases, epilepsy, autism, depression and traumatic brain injury. We also highlight future directions of research that could help to clarify the mechanisms and consequences of Shh signalling in the process of CNS development and related diseases. Significance of the study This review summarized the role of Shh signalling pathway in CNS development and related diseases such as brain tumour, Parkinson's diseases, epilepsy, autism, depression and traumatic brain injury. It also presented the author's opinions on the future research direction of Shh signalling pathway.
AbstractList Sonic hedgehog (Shh) plays important roles in developmental of vertebrate animal central nervous system (CNS), and Gli is its downstream signal molecule. Shh signalling is essential for pattern formation, cell‐fate specification, axon guidance, proliferation, survival and differentiation of neurons in CNS development. The abnormal signalling pathway of Shh leads to the occurrence of many nervous system diseases. The mechanism of Shh signalling is complex and remains incompletely understood. Nevertheless, studies have revealed that Shh signalling pathway is classified into canonical and non‐canonical pathways. Here we review the role of the Shh signalling pathway and its impact in CNS development and related diseases. Specifically, we discuss the role of Shh in the spinal cord and brain development, cell differentiation and proliferation in CNS and related diseases such as brain tumour, Parkinson's diseases, epilepsy, autism, depression and traumatic brain injury. We also highlight future directions of research that could help to clarify the mechanisms and consequences of Shh signalling in the process of CNS development and related diseases. Significance of the study This review summarized the role of Shh signalling pathway in CNS development and related diseases such as brain tumour, Parkinson's diseases, epilepsy, autism, depression and traumatic brain injury. It also presented the author's opinions on the future research direction of Shh signalling pathway.
Sonic hedgehog (Shh) plays important roles in developmental of vertebrate animal central nervous system (CNS), and Gli is its downstream signal molecule. Shh signalling is essential for pattern formation, cell-fate specification, axon guidance, proliferation, survival and differentiation of neurons in CNS development. The abnormal signalling pathway of Shh leads to the occurrence of many nervous system diseases. The mechanism of Shh signalling is complex and remains incompletely understood. Nevertheless, studies have revealed that Shh signalling pathway is classified into canonical and non-canonical pathways. Here we review the role of the Shh signalling pathway and its impact in CNS development and related diseases. Specifically, we discuss the role of Shh in the spinal cord and brain development, cell differentiation and proliferation in CNS and related diseases such as brain tumour, Parkinson's diseases, epilepsy, autism, depression and traumatic brain injury. We also highlight future directions of research that could help to clarify the mechanisms and consequences of Shh signalling in the process of CNS development and related diseases. SIGNIFICANCE OF THE STUDY: This review summarized the role of Shh signalling pathway in CNS development and related diseases such as brain tumour, Parkinson's diseases, epilepsy, autism, depression and traumatic brain injury. It also presented the author's opinions on the future research direction of Shh signalling pathway.
Sonic hedgehog (Shh) plays important roles in developmental of vertebrate animal central nervous system (CNS), and Gli is its downstream signal molecule. Shh signalling is essential for pattern formation, cell‐fate specification, axon guidance, proliferation, survival and differentiation of neurons in CNS development. The abnormal signalling pathway of Shh leads to the occurrence of many nervous system diseases. The mechanism of Shh signalling is complex and remains incompletely understood. Nevertheless, studies have revealed that Shh signalling pathway is classified into canonical and non‐canonical pathways. Here we review the role of the Shh signalling pathway and its impact in CNS development and related diseases. Specifically, we discuss the role of Shh in the spinal cord and brain development, cell differentiation and proliferation in CNS and related diseases such as brain tumour, Parkinson's diseases, epilepsy, autism, depression and traumatic brain injury. We also highlight future directions of research that could help to clarify the mechanisms and consequences of Shh signalling in the process of CNS development and related diseases.Significance of the studyThis review summarized the role of Shh signalling pathway in CNS development and related diseases such as brain tumour, Parkinson's diseases, epilepsy, autism, depression and traumatic brain injury. It also presented the author's opinions on the future research direction of Shh signalling pathway.
Author Li, Xiaoying
Li, Shuanqing
Yang, Ciqing
Li, Yunxiao
Li, Han
Lin, Juntang
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  fullname: Li, Yunxiao
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  surname: Li
  fullname: Li, Shuanqing
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  fullname: Li, Han
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  surname: Lin
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/32840890$$D View this record in MEDLINE/PubMed
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Keywords Sonic hedgehog
spinal cord
signalling pathway
brain
central nervous system
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Snippet Sonic hedgehog (Shh) plays important roles in developmental of vertebrate animal central nervous system (CNS), and Gli is its downstream signal molecule. Shh...
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SubjectTerms Autism
Axon guidance
Brain
Brain cancer
Brain research
Brain tumors
Cell differentiation
Central nervous system
Differentiation (biology)
Epilepsy
Head injuries
Hedgehog protein
Movement disorders
Nervous system
Nervous system diseases
Neurodegenerative diseases
Parkinson's disease
Pattern formation
Signal classification
Signal transduction
Signaling
signalling pathway
Sonic hedgehog
Spinal cord
Traumatic brain injury
Tumors
Vertebrates
Title The role of Shh signalling pathway in central nervous system development and related diseases
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fcbf.3582
https://www.ncbi.nlm.nih.gov/pubmed/32840890
https://www.proquest.com/docview/2498795914/abstract/
https://search.proquest.com/docview/2437129150
Volume 39
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