LncRNA LINC00899 promotes progression of acute myeloid leukaemia by modulating miR‐744‐3p/YY1 signalling

• Published in: Cell biochemistry and function Vol. 38; no. 7; pp. 955 - 964
• Main Authors: Dong, XueMei, Xu, Xin, Guan, YanPing
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.10.2020
• Subjects: 3' Untranslated Regions; acute myeloid leukaemia; Acute myeloid leukemia; Animals; Antagomirs - metabolism; Apoptosis; Cell growth; Cell Line, Tumor; Cell Proliferation; Disease Progression; Glioma; Humans; Kaplan-Meier Estimate; Leukemia; Leukemia, Myeloid, Acute - drug therapy; Leukemia, Myeloid, Acute - genetics; Leukemia, Myeloid, Acute - mortality; Leukemia, Myeloid, Acute - pathology; LINC00899; LncRNA; Mice; Mice, Nude; MicroRNAs - metabolism; miR‐744‐3p; Non-coding RNA; Prognosis; Ribonucleic acid; RNA; RNA Interference; RNA, Long Noncoding - antagonists & inhibitors; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; RNA, Small Interfering - metabolism; RNA, Small Interfering - therapeutic use; Signal Transduction; Signaling; Therapeutic applications; Tumors; Up-Regulation; Xenografts; Xenotransplantation; YY1; YY1 Transcription Factor - chemistry; YY1 Transcription Factor - genetics; YY1 Transcription Factor - metabolism; YY1; LncRNA; LINC00899; acute myeloid leukaemia; miR-744-3p

Long non‐coding RNA (lncRNA) LINC00899 is one kind cytoplasmic lncRNA, however, there is rarely little information about its function in physiological process. Here, we demonstrated that lncRNA LINC00899 was upregulated in acute myeloid leukaemia (AML) cells and was quite correlated with poor progno...