Multiple‐Dose Pharmacokinetics, Safety, and Tolerability of Aprocitentan, a Dual Endothelin Receptor Antagonist, in Healthy Japanese and Caucasian Subjects - Fontes, Magda S.C.; Dingemanse, Jasper; Sidharta, Patricia N. (Clinical pharmacology in drug development, 2021)
Keywords: Adult; Antagonist drugs; aprocitentan; Area Under Curve; Asians; Double-Blind Method; Drug dosages; endothelin receptor antagonist; Endothelin Receptor Antagonists - administration & dosage; Endothelin Receptor Antagonists - adverse effects; Endothelin Receptor Antagonists - pharmacokinetics; Ethnicity; Female; Half-Life; Humans; Japanese; Male; Pharmacokinetics; Pyrimidines - administration & dosage; Pyrimidines - adverse effects; Pyrimidines - pharmacokinetics; Sulfonamides - administration & dosage; Sulfonamides - adverse effects; Sulfonamides - pharmacokinetics; Whites; Young Adult; aprocitentan; pharmacokinetics; endothelin receptor antagonist; ethnicity; Japanese