Semaglutide (GLP‐1 receptor agonist) stimulates browning on subcutaneous fat adipocytes and mitigates inflammation and endoplasmic reticulum stress in visceral fat adipocytes of obese mice

• Published in: Cell biochemistry and function Vol. 40; no. 8; pp. 903 - 913
• Main Authors: Martins, Fabiane F., Marinho, Thatiany S., Cardoso, Luiz E. M., Barbosa‐da‐Silva, Sandra, Souza‐Mello, Vanessa, Aguila, Marcia B., Mandarim‐de‐Lacerda, Carlos A.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.12.2022
• Subjects: adipocyte; Adipocytes; Adipose tissue; Adipose Tissue, Brown; Adrenergic receptors; Agonists; Animals; Biomarkers; Biosynthesis; Body fat; Body weight loss; Browning; Cytokines; Diet; Diet, High-Fat; DNA damage; Endoplasmic reticulum; Endoplasmic Reticulum Stress; Fibronectin; Food; Food intake; Glucagon-Like Peptide-1 Receptor - agonists; High fat diet; Hypertrophy; Immunohistochemistry; Infiltration; Inflammation; Inflammation - drug therapy; Interleukins; Intra-Abdominal Fat - metabolism; Leptin; Macrophages; Male; Metastases; Mice; Mice, Inbred C57BL; Mice, Obese; Mitochondria; Monocyte chemoattractant protein; Monocytes; Obesity; Obesity - metabolism; Peroxisome Proliferator-Activated Receptors; Phenotypes; Polymerase chain reaction; Proteins; Receptors (physiology); Reduction; Reverse transcription; Stereology; Subcutaneous Fat; Transcription factors; Weight control; Weight Loss; browning; inflammation; mice; endoplasmic reticulum stress; obesity; adipocyte

Semaglutide (GLP‐1 agonist) was approved for treating obesity. Although the effects on weight loss and metabolism are known, the responses of adipocytes to semaglutide are yet limited. C57BL/6 male mice (n = 20/group) were fed a control diet (C) or a high‐fat (HF) diet for 16 weeks and then separate...