One-step electrodeposition preparation of polyaniline/f-MWCNTs as electrochemical sensors for detection of 10-hydroxycamptothecine

• Published in: Biotechnology and applied biochemistry Vol. 68; no. 6; p. 1192
• Main Authors: Meng, Lingqiang, Dai, Jianmin, Rong, Shengzhong, Gao, Hongmin, Zhang, Ze, Zhang, Yingcong, Chang, Dong, Pan, Hongzhi
• Format: Journal Article
• Language: English
• Published: United States 01.12.2021
• Subjects: Aniline Compounds - chemistry; Biosensing Techniques; Camptothecin - analogs & derivatives; Camptothecin - analysis; Electrochemical Techniques; Electrodes; Nanotubes, Carbon - chemistry; electrochemical detection; MWCNTs; 10-hydroxycamptothecine; polyaniline
• DOI: 10.1002/bab.2041

In our work, one-step electro-deposition method was adopted to produce polyaniline (PANI) and functional multiwalled carbon nanotubes (f-MWCNTs) films on glass carbon electrodes, and the modified electrodes were applied as an electrochemical sensor for determination of 10-hydroxycamptothecine (10-HCPT). The f-MWCNTs were handled by ultrasound processing in concentrated oxidizing acid solution, which can obtain a wonderful dissolution in water and attach new functional groups, such as -COOH and -OH. Then, aniline monomer could polymerize on the surface easily. The surface characterization was investigated using various techniques including scanning electron microscope, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and X-ray diffraction, and electro-catalytic properties were characterized by cyclic voltammetry and electrochemical impedance spectroscopy. Under optimal conditions, the resulting of PANI/f-MWCNTs sensor showed a wide linear range (3 × 10 to 7 × 10 mol L ) and a low detection limit (1 10 mol L ), which is attributing to its large special surface area and good conductivity. Moreover, the modified electrodes are convenient to fabricate, which can be used to detect 10-HCPT in urine samples successfully.