Human umbilical cord mesenchymal stem cells alleviate fatty liver ischemia‐reperfusion injury by activating autophagy through upregulation of IFNγ

• Published in: Cell biochemistry and function Vol. 42; no. 4; pp. e4040 - n/a
• Main Authors: Xu, Chenhao, Fang, Xixi, Lu, Bei, Song, Yisu, Shu, Wenzhi, Lu, Zhengyang, Su, Renyi, Xiang, Ze, Xu, Xiao, Wei, Xuyong
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.06.2024
• Subjects: Animals; Apoptosis; Autophagy; cellular autophagy; Disease Models, Animal; Fatty liver; Fatty Liver - metabolism; Fatty Liver - pathology; Fatty Liver - therapy; Hepatocytes; Humans; Inflammation; Injuries; Interferon-gamma - metabolism; Ischemia; ischemia‐reperfusion injury; Liver; Liver transplantation; Liver transplants; Male; MAP kinase; Mesenchymal Stem Cell Transplantation; Mesenchymal stem cells; Mesenchymal Stem Cells - cytology; Mesenchymal Stem Cells - metabolism; Mice; Mice, Inbred C57BL; Reperfusion; Reperfusion Injury - metabolism; Reperfusion Injury - pathology; Reperfusion Injury - therapy; Steatosis; Stem cell transplantation; Stem cells; Transcriptomics; Transplantation; Umbilical cord; Umbilical Cord - cytology; Umbilical Cord - metabolism; Up-Regulation; γ-Interferon; ischemia‐reperfusion injury; fatty liver; cellular autophagy; mesenchymal stem cells

Liver ischemia‐reperfusion injury (IRI) is an important factor affecting the prognosis of liver transplantation, and extended criteria donors (e.g., steatosis donor livers) are considered to be more sensitive to ischemia‐reperfusion injury in liver transplantation. Currently, the application of huma...