MEBoost: Variable selection in the presence of measurement error

• Published in: Statistics in medicine Vol. 38; no. 15; pp. 2705 - 2718
• Main Authors: Brown, Ben, Weaver, Timothy, Wolfson, Julian
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 10.07.2019
• Subjects: Algorithms; boosting; high‐dimensional data; machine learning; measurement error; Measurement errors; Medical statistics; Regression analysis; variable selection; Variables; measurement error; variable selection; boosting; machine learning; high-dimensional data
• DOI: 10.1002/sim.8130
• ISSN: 0277-6715; 1097-0258

We present a novel method for variable selection in regression models when covariates are measured with error. The iterative algorithm we propose, Measurement Error Boosting (MEBoost), follows a path defined by estimating equations that correct for covariate measurement error. We illustrate the use of MEBoost in practice by analyzing data from the Box Lunch Study, a clinical trial in nutrition where several variables are based on self‐report and, hence, measured with error, where we are interested in performing model selection from a large data set to select variables that are related to the number of times a subject binge ate in the last 28 days. Furthermore, we evaluated our method and compared its performance to the recently proposed Convex Conditioned Lasso and to the “naive” Lasso, which does not correct for measurement error through a simulation study. Increasing the degree of measurement error increased prediction error and decreased the probability of accurate covariate selection, but this loss of accuracy occurred to a lesser degree when using MEBoost. Through simulations, we also make a case for the consistency of the model selected.