A randomized, controlled crossover trial of ondansetron in patients with primary biliary cirrhosis and fatigue

• Published in: Hepatology (Baltimore, Md.) Vol. 41; no. 6; pp. 1305 - 1312
• Main Authors: Theal, Jeremy J., Toosi, Mohssen N., Girlan, Larisa, Heslegrave, Ronald J., Huet, Pierre‐Michel, Burak, Kelly W., Swain, Mark, Tomlinson, George A., Heathcote, E. Jenny
• Format: Journal Article
• Language: English
• Published: Hoboken, NJ Wiley 01.06.2005
• Subjects: Biological and medical sciences; Constipation - chemically induced; Cross-Over Studies; Fatigue - drug therapy; Fatigue - etiology; Fatigue - physiopathology; Fundamental and applied biological sciences. Psychology; Gastroenterology. Liver. Pancreas. Abdomen; Headache - chemically induced; Humans; Liver Cirrhosis, Biliary - complications; Liver. Bile. Biliary tracts; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Medical sciences; Middle Aged; Ondansetron - adverse effects; Ondansetron - therapeutic use; Other diseases. Semiology; Patient Compliance; Serotonin Antagonists - adverse effects; Serotonin Antagonists - therapeutic use; Severity of Illness Index; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Treatment Failure; Vertebrates: digestive system; Primary biliary cirrhosis; Pathogenesis; Toxicity; Transmission; Check; Hepatic disease; Prevention; Microbiological investigation; Gastroenterology; Secondary effect; Intestinal disease; Constipation; Human; Typing; Evaluation scale; Serotonin antagonist; Oral administration; Fatigue; Symptomatology; 5-HT3 Serotonine receptor; Digestive diseases; Severity score; Subtype; Antiemetic; Comparative study; Ondansetron

Fatigue is common in primary biliary cirrhosis (PBC). Altered central serotonergic neurotransmission may be involved in its pathogenesis. This multicenter, randomized, double-blind, placebo-controlled, crossover trial evaluated the efficacy of ondansetron, a selective 5-HT3 receptor subtype antagoni...