Quartz crystal microbalance analysis of growth kinetics for aggregation intermediates of the amyloid-β protein

• Published in: Analytical biochemistry Vol. 378; no. 1; pp. 15 - 24
• Main Authors: Kotarek, Joseph A., Johnson, Kathryn C., Moss, Melissa A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2008
• Subjects: Alzheimer’s disease; Amyloid beta-Peptides - analysis; Amyloid beta-Peptides - chemistry; Amyloid-β protein; Biotin - chemistry; Crystallization; Elongation; Growth kinetics; Hydrogen-Ion Concentration; Kinetics; Models, Biological; Osmolar Concentration; Peptide Fragments - analysis; Peptide Fragments - chemistry; Protein Binding; Quartz; Quartz crystal microbalance; Sensitivity and Specificity; Soluble aggregation intermediates; Amyloid-β protein; Soluble aggregation intermediates; Quartz crystal microbalance; Alzheimer’s disease; Elongation; Growth kinetics

Evidence linking soluble aggregation intermediates of the amyloid-β protein (Aβ), as well as the ongoing growth of Aβ aggregates, to physiological responses characteristic of Alzheimer’s disease (AD) indicates that a kinetic description Aβ aggregation intermediate growth may be fundamental to unders...