Reduced GLP-1 Secretion at 30 Minutes After a 75-g Oral Glucose Load Is Observed in Gestational Diabetes Mellitus: A Prospective Cohort Study

• Published in: Diabetes (New York, N.Y.) Vol. 67; no. 12; pp. 2650 - 2656
• Main Authors: Sukumar, Nithya, Bagias, Christos, Goljan, Ilona, Weldeselassie, Yonas, Gharanei, Seley, Tan, Bee K, Holst, Jens J, Saravanan, Ponnusamy
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.12.2018
• Subjects: Cohort analysis; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Gestational age; Gestational diabetes; Glucagon; Glucagon-like peptide 1; Glucose; Glucose tolerance; Hyperglycemia; Hyperinsulinemia; Insulin; Insulin secretion; Minority & ethnic groups; Secretion

Glucagon-like peptide 1 (GLP-1) levels may be reduced in type 2 diabetes, but whether a similar impairment exists in gestational diabetes mellitus (GDM) has not been established. We studied this in a prospective cohort study of pregnant women ( = 144) during oral glucose tolerance test (OGTT). GLP-1...