Selective separation of structure-related alkaloids in Rhizoma coptidis with “click” binaphthyl stationary phase and their structural elucidation with liquid chromatography-mass spectrometry

• Published in: Analyst (London) Vol. 136; no. 20; pp. 4357 - 4365
• Main Authors: Liu, Qiaoxia, Qiu, Shiyi, Yu, Hui, Ke, Yanxiong, Jin, Yu, Liang, Xinmiao
• Format: Journal Article
• Language: English
• Published: Cambridge Royal Society of Chemistry 21.10.2011
• Subjects: Alkaloids; Alkaloids - chemistry; Alkaloids - isolation & purification; Analytical chemistry; Aporphines - chemistry; Aporphines - isolation & purification; Benzene; Berberine Alkaloids - chemistry; Berberine Alkaloids - isolation & purification; Chemistry; Chromatographic methods and physical methods associated with chromatography; Chromatography; Chromatography, High Pressure Liquid; Click Chemistry; Columns (structural); Exact sciences and technology; Fragmentation; Liquids; Medicine, Chinese Traditional; Naphthalenes - chemistry; Other chromatographic methods; Rhizome - chemistry; Separation; Spectrometric and optical methods; Spectrometry; Spectrometry, Mass, Electrospray Ionization; Molecules; Separation method; Alkaloid; Coupled method; Benzene; Sample; Interference; Liquid chromatography; Retention; Mass spectrometry; Fragmentation; Stationary phase

It is a new task to separate structure-related compounds into a fraction according to their structural characteristics in a complex traditional Chinese medicine (TCM). This method makes separation of the components of the sample simple and structural elucidation easy. In this study, selective separa...