Clinically Relevant Circulating Protein Biomarkers for Type 1 Diabetes: Evidence From a Two-Sample Mendelian Randomization Study

• Published in: Diabetes care Vol. 45; no. 1; pp. 169 - 177
• Main Authors: Yazdanpanah, Nahid, Yazdanpanah, Mojgan, Wang, Ye, Forgetta, Vincenzo, Pollak, Michael, Polychronakos, Constantin, Richards, J. Brent, Manousaki, Despoina
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.01.2022
• Subjects: Biomarkers; Diabetes; Diabetes mellitus; Diabetes mellitus (insulin dependent); Diabetes Mellitus, Type 1 - genetics; Drug development; Drug screening; Epstein-Barr virus; Epstein-Barr Virus Infections; Gene mapping; Genome-Wide Association Study - methods; Genomes; Health risks; Herpesvirus 4, Human; Humans; Interleukin 27; Interleukins; Mendelian Randomization Analysis - methods; Pleiotropy; Polymorphism, Single Nucleotide; Proteins; Quantitative trait loci; Randomization; Research design; Risk; Robust control; Sensitivity analysis

To identify circulating proteins influencing type 1 diabetes susceptibility using Mendelian randomization (MR). We used a large-scale two-sample MR study, using cis genetic determinants (protein quantitative trait loci [pQTL]) of up to 1,611 circulating proteins from five large genome-wide associati...