A review of self-healing hydrogels for bone repair and regeneration: Materials, mechanisms, and applications

Bone defects, which arise from various factors such as trauma, tumor resection, and infection, present a significant clinical challenge. There is an urgent need to develop new biomaterials capable of repairing a wide array of damage and defects in bone tissue. Self-healing hydrogels, a groundbreakin...

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Published inInternational journal of biological macromolecules Vol. 287; p. 138323
Main Authors Li, Bo, Li, Chenchen, Yan, Ziyi, Yang, Xiaoling, Xiao, Wenqian, Zhang, Dawei, Liu, Zhongning, Liao, Xiaoling
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.01.2025
Subjects
Animals
biocompatibility
biocompatible materials
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacology
Bone and Bones - drug effects
bone formation
Bone Regeneration - drug effects
Bone repair
bones
Humans
Hydrogel
hydrogels
Hydrogels - chemistry
Hydrogels - pharmacology
Hydrogels - therapeutic use
neoplasms
Osteogenesis - drug effects
resection
Self-healing
Tissue Engineering
tissue repair
Wound Healing - drug effects
Bone repair
Self-healing
Hydrogel
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Abstract Bone defects, which arise from various factors such as trauma, tumor resection, and infection, present a significant clinical challenge. There is an urgent need to develop new biomaterials capable of repairing a wide array of damage and defects in bone tissue. Self-healing hydrogels, a groundbreaking advancement in the field of biomaterials, displaying remarkable ability to regenerate damaged connections after partial severing, thus offering a promising solution for bone defect repair. This review first presents a comprehensive overview of the progress made in the design and preparation of these hydrogels, focusing on the self-healing mechanisms based on physical non-covalent interactions and dynamic chemical covalent bonds. Subsequently, the applications of self-healing hydrogels including natural polymers, synthetic polymers, and nano-hybrid materials, are discussed in detail, emphasizing their mechanisms in promoting bone tissue regeneration. Finally, the review addresses current challenges as well as future prospects for the use of hydrogels in bone repair and regeneration, identifying osteogenic properties, mechanical performance, and long-term biocompatibility as key areas for further improvement. In summary, this paper provides an in-depth analysis of recent advances in self-healing hydrogels for bone repair and regeneration, underscoring their immense potential for clinical application.
AbstractList Bone defects, which arise from various factors such as trauma, tumor resection, and infection, present a significant clinical challenge. There is an urgent need to develop new biomaterials capable of repairing a wide array of damage and defects in bone tissue. Self-healing hydrogels, a groundbreaking advancement in the field of biomaterials, displaying remarkable ability to regenerate damaged connections after partial severing, thus offering a promising solution for bone defect repair. This review first presents a comprehensive overview of the progress made in the design and preparation of these hydrogels, focusing on the self-healing mechanisms based on physical non-covalent interactions and dynamic chemical covalent bonds. Subsequently, the applications of self-healing hydrogels including natural polymers, synthetic polymers, and nano-hybrid materials, are discussed in detail, emphasizing their mechanisms in promoting bone tissue regeneration. Finally, the review addresses current challenges as well as future prospects for the use of hydrogels in bone repair and regeneration, identifying osteogenic properties, mechanical performance, and long-term biocompatibility as key areas for further improvement. In summary, this paper provides an in-depth analysis of recent advances in self-healing hydrogels for bone repair and regeneration, underscoring their immense potential for clinical application.
Bone defects, which arise from various factors such as trauma, tumor resection, and infection, present a significant clinical challenge. There is an urgent need to develop new biomaterials capable of repairing a wide array of damage and defects in bone tissue. Self-healing hydrogels, a groundbreaking advancement in the field of biomaterials, displaying remarkable ability to regenerate damaged connections after partial severing, thus offering a promising solution for bone defect repair. This review first presents a comprehensive overview of the progress made in the design and preparation of these hydrogels, focusing on the self-healing mechanisms based on physical non-covalent interactions and dynamic chemical covalent bonds. Subsequently, the applications of self-healing hydrogels including natural polymers, synthetic polymers, and nano-hybrid materials, are discussed in detail, emphasizing their mechanisms in promoting bone tissue regeneration. Finally, the review addresses current challenges as well as future prospects for the use of hydrogels in bone repair and regeneration, identifying osteogenic properties, mechanical performance, and long-term biocompatibility as key areas for further improvement. In summary, this paper provides an in-depth analysis of recent advances in self-healing hydrogels for bone repair and regeneration, underscoring their immense potential for clinical application.Bone defects, which arise from various factors such as trauma, tumor resection, and infection, present a significant clinical challenge. There is an urgent need to develop new biomaterials capable of repairing a wide array of damage and defects in bone tissue. Self-healing hydrogels, a groundbreaking advancement in the field of biomaterials, displaying remarkable ability to regenerate damaged connections after partial severing, thus offering a promising solution for bone defect repair. This review first presents a comprehensive overview of the progress made in the design and preparation of these hydrogels, focusing on the self-healing mechanisms based on physical non-covalent interactions and dynamic chemical covalent bonds. Subsequently, the applications of self-healing hydrogels including natural polymers, synthetic polymers, and nano-hybrid materials, are discussed in detail, emphasizing their mechanisms in promoting bone tissue regeneration. Finally, the review addresses current challenges as well as future prospects for the use of hydrogels in bone repair and regeneration, identifying osteogenic properties, mechanical performance, and long-term biocompatibility as key areas for further improvement. In summary, this paper provides an in-depth analysis of recent advances in self-healing hydrogels for bone repair and regeneration, underscoring their immense potential for clinical application.
ArticleNumber 138323
Author Li, Bo
Liao, Xiaoling
Zhang, Dawei
Yan, Ziyi
Liu, Zhongning
Xiao, Wenqian
Li, Chenchen
Yang, Xiaoling
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– sequence: 4
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  givenname: Dawei
  surname: Zhang
  fullname: Zhang, Dawei
  email: zdwasy6161@163.com
  organization: Department of Orthopedics, The 960th Hospital of the PLA Joint Logistice Support Force, Jinan 250031, China
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  givenname: Zhongning
  surname: Liu
  fullname: Liu, Zhongning
  email: liuzhongning@bjmu.edu.cn
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Snippet Bone defects, which arise from various factors such as trauma, tumor resection, and infection, present a significant clinical challenge. There is an urgent...
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SubjectTerms Animals
biocompatibility
biocompatible materials
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacology
Bone and Bones - drug effects
bone formation
Bone Regeneration - drug effects
Bone repair
bones
Humans
Hydrogel
hydrogels
Hydrogels - chemistry
Hydrogels - pharmacology
Hydrogels - therapeutic use
neoplasms
Osteogenesis - drug effects
resection
Self-healing
Tissue Engineering
tissue repair
Wound Healing - drug effects
Title A review of self-healing hydrogels for bone repair and regeneration: Materials, mechanisms, and applications
URI https://dx.doi.org/10.1016/j.ijbiomac.2024.138323
https://www.ncbi.nlm.nih.gov/pubmed/39645113
https://www.proquest.com/docview/3146569090
https://www.proquest.com/docview/3165873944
Volume 287
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