Identification of ARHGEF11 (PDZ-RhoGEF) as an in vivo regulator of synapses and cognition

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 122; no. 4; p. e2415316122
• Main Authors: Bjornson, Kathryn J., Kermath, Bailey A., Cahill, Michael E.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 28.01.2025
• Subjects: Animals; Biological Sciences; Cognition - physiology; Dendritic Spines - metabolism; Humans; Mice; MicroRNAs - genetics; MicroRNAs - metabolism; Prefrontal Cortex - metabolism; Rho Guanine Nucleotide Exchange Factors - genetics; Rho Guanine Nucleotide Exchange Factors - metabolism; Synapses - metabolism; dendritic spine; learning; memory; cognition; mir132

Given the influence of cognitive abilities on life outcomes, there is inherent value in identifying genes involved in controlling learning and memory. Further, cognitive dysfunction is a core feature of many neuropsychiatric disorders. Here, we use a combinatory in silico approach to identify human...