Quantifying the Evolution of SNPs That Affect RNA Secondary Structure in Arabidopsis thaliana Genes

• Published in: Molecular biology and evolution Vol. 42; no. 6
• Main Authors: Martin, Galen T, Fiscus, Christopher J, Gaut, Brandon S
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 10.06.2025
• Subjects: Arabidopsis - genetics; Discoveries; Evolution, Molecular; Gene Frequency; Genes, Plant; Nucleic Acid Conformation; Polymorphism, Single Nucleotide; RNA, Plant - chemistry; RNA, Plant - genetics; Selection, Genetic; secondary structure; purifying selection; RNA biology; bioclimate; gene expression

Single-stranded RNA molecules can form intramolecular bonds between nucleotides to create secondary structures. These structures can have phenotypic effects, meaning mutations that alter secondary structure may be subject to natural selection. Here, we examined the population genetics of these mutat...