The roles and implications of RNA m6A modification in cancer

• Published in: Nature reviews. Clinical oncology Vol. 20; no. 8; pp. 507 - 526
• Main Authors: Deng, Xiaolan, Qing, Ying, Horne, David, Huang, Huilin, Chen, Jianjun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group 01.08.2023
• Subjects: Biomarkers; Cancer; Cancer therapies; Cell self-renewal; Metastases; Molecular modelling; mRNA; N6-methyladenosine; Phenotypes; RNA modification; Tumor microenvironment; Tumors

N6-Methyladenosine (m6A), the most prevalent internal modification in eukaryotic mRNA, has been extensively and increasingly studied over the past decade. Dysregulation of RNA m6A modification and its associated machinery, including writers, erasers and readers, is frequently observed in various can...