High Precision DNA Modification Analysis of HCG9 in Major Psychosis

• Published in: Schizophrenia bulletin Vol. 42; no. 1; pp. sbv079 - 177
• Main Authors: Pal, Mrinal, Ebrahimi, Sasha, Oh, Gabriel, Khare, Tarang, Zhang, Aiping, Kaminsky, Zachary A., Wang, Sun-Chong, Petronis, Arturas
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.01.2016
• Subjects: Adult; Aged; Aged, 80 and over; Bipolar Disorder - genetics; Bipolar Disorder - metabolism; Brain - metabolism; Cadaver; Case-Control Studies; DNA - metabolism; DNA Methylation; Epigenesis, Genetic; Female; Humans; Male; Middle Aged; Prefrontal Cortex - metabolism; Psychotic Disorders - genetics; Psychotic Disorders - metabolism; Regular; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Schizophrenia - genetics; Schizophrenia - metabolism; Sequence Analysis, DNA; bipolar disorder; bisulfite sequencing; schizophrenia; brain; epigenetics; padlock probes

New epigenetic technologies may uncover etiopathogenic mechanisms of major psychosis. In this study, we applied padlock probe-based ultra-deep bisulfite sequencing for fine mapping of modified cytosines of the HLA complex group 9 (nonprotein coding) gene in the postmortem brains of individuals affec...