Neurofilament Biophysics: from Structure to Biomechanics

• Published in: Molecular biology of the cell Vol. 35; no. 5; p. mbcE23110438
• Main Authors: Ding, Erika A, Kumar, Sanjay
• Format: Journal Article
• Language: English
• Published: United States The American Society for Cell Biology 01.05.2024
• Subjects: Special Issue on Cell Biology of the Nervous System

Neurofilaments (NFs) are multi-subunit, neuron-specific intermediate filaments consisting of a 10-nm diameter filament "core" surrounded by a layer of long intrinsically disordered protein (IDP) "tails." NFs are thought to regulate axonal caliber during development and then stabi...