Uncovering the heterogeneity of NK cells on the prognosis of HCC by integrating bulk and single-cell RNA-seq data

• Published in: Frontiers in oncology Vol. 15; p. 1570647
• Main Authors: Li, Jiashuo, Liu, Zhenyi, Zhang, Gongming, Yin, Xue, Yuan, Xiaoxue, Xie, Wen, Ding, Xiaoyan
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 18.03.2025
• Subjects: hepatocellular carcinoma; natural kill cell; nomogram; Oncology; prognosis; TUBA1B; tumor microenvironment; TUBA1B; single-cell; nomogram; tumor microenvironment; natural kill cell; prognosis; hepatocellular carcinoma
• ISSN: 2234-943X; 2234-943X
• DOI: 10.3389/fonc.2025.1570647

The tumor microenvironment (TME) plays a critical role in the development, progression, and clinical outcomes of hepatocellular carcinoma (HCC). Despite the critical role of natural killer (NK) cells in tumor immunity, there is limited research on their status within the tumor microenvironment of HC...