The Pathogenicity and Synergistic Action of Th1 and Th17 Cells in Inflammatory Bowel Diseases

• Published in: Inflammatory bowel diseases Vol. 29; no. 5; pp. 818 - 829
• Main Authors: Cao, Hui, Diao, Jun, Liu, Huosheng, Liu, Suxian, Liu, Jun, Yuan, Jianye, Lin, Jiang
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 02.05.2023
• Subjects: Animals; Colitis - pathology; Homeostasis; Inflammation; Inflammation - pathology; Inflammatory bowel disease; Inflammatory Bowel Diseases - pathology; Interferon-gamma - metabolism; Intestinal Mucosa - pathology; Pathogenesis; Th1 Cells - metabolism; Th17 Cells; Virulence; intestine homeostasis; IBD; Th1 cells; pathogenic Th17 cells; synergistic action
• ISSN: 1078-0998; 1536-4844; 1536-4844
• DOI: 10.1093/ibd/izac199

Abstract Inflammatory bowel diseases (IBDs), including ulcerative colitis and Crohn’s disease, are characterized by chronic idiopathic inflammation of gastrointestinal tract. Although the pathogenesis of IBD remains unknown, intestinal immune dysfunction has been considered as the core pathogenesis....