Estimating optimally tailored active surveillance strategy under interval censoring

• Published in: Biometrics Vol. 81; no. 2
• Main Authors: Liang, Muxuan, Zhao, Yingqi, Lin, Daniel W, Cooperberg, Matthew, Zheng, Yingye
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 02.04.2025
• Subjects: Biometric Methodology; Biopsy - statistics & numerical data; Computer Simulation; Cost-Benefit Analysis; Disease Progression; Humans; Male; Models, Statistical; Prostatic Neoplasms - diagnosis; Prostatic Neoplasms - pathology; Statistics, Nonparametric; Watchful Waiting - methods; Watchful Waiting - statistics & numerical data; cancer surveillance; decision-making; interval censoring; generalization error; missing data

Active surveillance (AS) using repeated biopsies to monitor disease progression has been a popular alternative to immediate surgical intervention in cancer care. However, a biopsy procedure is invasive and sometimes leads to severe side effects of infection and bleeding. To reduce the burden of repe...