Dual-palindrome-incorporated hand-in-hand self-linking bidirectional DNA amplifier within exogenous near-infrared light stimulation for high-performance imaging in living biosystems

• Published in: Talanta (Oxford) Vol. 292; p. 128003
• Main Authors: Zhang, Tian-Tian, Sun, Xiao-Ming, Chen, Wei-Lin, Chen, Xiao-Xue, Li, Cheng-Yu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2025
• Subjects: biomarkers; Biosensing Techniques - methods; Biosensor; biosensors; diagnostic techniques; DNA; DNA - chemistry; DNA - genetics; DNA amplifier; Humans; Imaging; In vivo; Infrared Rays; Inverted Repeat Sequences; Living cells; luminescence; MicroRNAs - analysis; MicroRNAs - genetics; Near-infrared light; DNA amplifier; In vivo; Living cells; Near-infrared light; Biosensor; Imaging

Although the potency of DNA amplifiers-constructed biosensors for imaging disease biomarkers in living biosystems, they continue to face two challenges: (i) intricate multi-pathway amplification cascades in biosensing designs and (ii) suboptimal detection precision due to uncontrollable pre-activati...