Improved concordance of challenging human epidermal growth factor receptor 2 dual in-situ hybridisation cases with the use of a digital image analysis algorithm in breast cancer

• Published in: Histopathology Vol. 83; no. 4; pp. 647 - 656
• Main Authors: Gough, Madeline, Liu, Cheng, Srinivasan, Bhuvana, Wilkinson, Lisa, Dunk, Louisa, Yang, Yuanhao, Schreiber, Veronika, Tuffaha, Haitham, Kryza, Thomas, Hooper, John D, Lakhani, Sunil R, Snell, Cameron E
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.10.2023
• Subjects: Algorithms; Breast cancer; Copy number; Epidermal growth factor; ErbB-2 protein; Hybridization; Image processing; Immunohistochemistry; Light microscopy; Microscopy; bright-field ISH; in-situ hybridisation; digital pathology; ERBB2; breast cancer; HER2; image analysis

Accurate assessment of human epidermal growth factor receptor 2 (HER2) expression by HER2 immunohistochemistry and in-situ hybridisation (ISH) is critical for the management of patients with breast cancer. The revised 2018 ASCO/CAP guidelines define 5 groups based on HER2 expression and copy number....