A Circuit Topology Approach to Categorizing Changes in Biomolecular Structure

• Published in: Frontiers in physics Vol. 8
• Main Authors: Schullian, Otto, Woodard, Jaie, Tirandaz, Arash, Mashaghi, Alireza
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 30.01.2020
• Subjects: duplication; matrix representation; permutation; protein engineering; protein folding; topology

The biological world is composed of folded linear molecules of bewildering topological complexity and diversity. The topology of folded biomolecules such as proteins and ribonucleic acids is often subject to change during biological processes. Despite intense research, we lack a solid mathematical f...