Capillary electrophoresis for the quality control of chondroitin sulfates in raw materials and formulations

• Published in: Analytical biochemistry Vol. 374; no. 1; pp. 213 - 220
• Main Authors: Malavaki, Christina J., Asimakopoulou, Athanasia P., Lamari, Fotini N., Theocharis, Achilleas D., Tzanakakis, George N., Karamanos, Nikos K.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2008
• Subjects: Analysis; Animals; Capillary electrophoresis; Capsules - analysis; Cartilage - chemistry; Chemistry, Pharmaceutical - standards; Chondroitin ABC Lyase - metabolism; Chondroitin Lyases - metabolism; Chondroitin sulfate; Chondroitin Sulfates - isolation & purification; Chondroitin Sulfates - metabolism; Chondroitin Sulfates - standards; Disaccharides - analysis; Electrophoresis, Capillary - methods; Hyaluronan impurities; Hyaluronic Acid - analysis; Hyaluronic Acid - isolation & purification; Nutritional supplements; Quality Control; Reproducibility of Results; Sharks; Tablets - analysis; Chondroitin sulfate; Capillary electrophoresis; Hyaluronan impurities; Nutritional supplements; Analysis

Exogenous administration of chondroitin sulfate (CS) is widely practiced for the treatment of osteoarthritis, although the efficacy of this treatment has not been completely established by clinical studies. A reason for the inconsistency of the results may be the quality of the CS preparations, whic...