Pseudomonas aeruginosa with LasI Quorum-Sensing Deficiency during Corneal Infection

• Published in: Investigative ophthalmology & visual science Vol. 45; no. 6; pp. 1897 - 1903
• Main Authors: Zhu, Hua, Bandara, Rani, Conibear, Tim C. R, Thuruthyil, Sophy J, Rice, Scott A, Kjelleberg, Staffan, Givskov, Michael, Willcox, Mark D. P
• Format: Journal Article
• Language: English
• Published: Rockville, MD ARVO 01.06.2004; Association for Research in Vision and Ophtalmology
• Subjects: Animals; Bacterial Proteins - physiology; Bacterial Typing Techniques; Biological and medical sciences; Blotting, Southern; Cornea - microbiology; Corneal Ulcer - microbiology; Diseases of cornea, anterior segment and sclera; DNA-Binding Proteins - physiology; Eye Infections, Bacterial - microbiology; Female; Medical sciences; Mice; Mice, Inbred BALB C; Ophthalmology; Phenotype; Polymerase Chain Reaction; Pseudomonas aeruginosa - classification; Pseudomonas aeruginosa - genetics; Pseudomonas aeruginosa - pathogenicity; Pseudomonas Infections - microbiology; Trans-Activators - physiology; Virulence; Eye; Pseudomonadales; Infection; Visual system; Cornea; Deficiency; Bacteria; Pseudomonadaceae; Pseudomonas aeruginosa; Ophthalmology

To understand the importance of Pseudomonas aeruginosa quorum-sensing systems in the development of corneal infection, the genotypic characteristics and pathogenesis of seven ocular isolates with low-protease and acyl homoserine lactone (AHL) activity and quorum-sensing mutants of PAO1 deficient in...