A novel fungal-targeted drug delivery system dectin-1-targeted-PEG-amino acid polymer block enhances antifungal activity and reduces cytotoxicity of amphotericin B

• Published in: Journal of drug delivery science and technology Vol. 100; p. 106073
• Main Authors: Inukai, Tatsuya, Chen, Pengwen, Kokuba, Hiroko, Cabral, Horacio, Nakamura, Shigeki
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.10.2024
• Subjects: Amphotericin B; Aspergillus fumigatus; Drug delivery system; Amphotericin B; Aspergillus fumigatus; Drug delivery system

We investigated whether the cytotoxicity of the antifungal drug amphotericin B (AmB) could be mitigated using Dectin-1 (DEC)-installed-polymeric micelles based on poly(ethylene glycol) (PEG)-amino acid block copolymers. In this study, DEC-installed micelles formed by carboxydimethylmaleic anhydride-...