A mesoporous MnO2-based nanoplatform with near infrared light-controlled nitric oxide delivery and tumor microenvironment modulation for enhanced antitumor therapy

• Published in: Journal of inorganic biochemistry Vol. 241; p. 112133
• Main Authors: Zhang, Hai-Lin, Wang, Yi, Tang, Qi, Ren, Bing, Yang, Shi-Ping, Liu, Jin-Gang
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.04.2023
• Subjects: Fenton-like reaction; Manganese dioxide; Nitric oxide delivery; Ruthenium nitrosyl; Synergistic therapy; Tumor microenvironment modulation; NO; AFIPB; Tumor microenvironment modulation; EDC; MRI; MTT; PDA; Manganese dioxide; PTT; CDT; H-MnO2; RDPP; MB; FTIR; Ruthenium nitrosyl; NHS; OH; XPS; CLSM; GSH; Synergistic therapy; PBS; DTNB; Nitric oxide delivery; TME; BET; NPs; DCFH-DA; NIR; ROS; Fenton-like reaction; FA; TEM

A hollow mesoporous manganese dioxide-based (H-MnO2) multifunctional nanoplatform, H-MnO2 @AFIPB@PDA@Ru-NO@FA (MAPRF NPs), was prepared for synergistic cancer treatment, in which a histone deacetylase inhibitor AFIPB was loaded in its hollow cavity and a ruthenium nitrosyl donor (Ru-NO) and a folic...