Association between papillary thyroid cancer and XRCC6 gene polymorphisms in the Turkish population

• Published in: Turkish journal of medical sciences Vol. 54; no. 6; pp. 1215 - 1222
• Main Authors: AKGÜN, EGEMEN, MUTLU İÇDUYGU, FADİME, ŞENGÜL, DEMET, ALP, EBRU, ALKANAT, MEHMET, CEBİ, AYSEGÜL, OZTURK, TUNCER
• Format: Journal Article
• Language: English
• Published: Turkey Scientific and Technological Research Council of Turkey (TUBITAK) 01.01.2024
• Subjects: Adult; Case-Control Studies; Female; Genetic Predisposition to Disease - genetics; Genotype; Humans; Ku Autoantigen - genetics; Male; Middle Aged; Polymorphism, Single Nucleotide - genetics; Thyroid Cancer, Papillary - genetics; Thyroid Neoplasms - epidemiology; Thyroid Neoplasms - genetics; Turkey - epidemiology; Turkey; XRCC6; polymorphism; PCR-RFLP; genotype-tissue expression; papillary thyroid cancer

To investigate the association between the rs2267437, rs5751129 and rs132770 polymorphisms of the gene, which plays a role in repairing DNA double-strand breaks, and the risk of papillary thyroid carcinoma (PTC). The study included 150 patients who had been diagnosed with PTC and 204 healthy control...