Total plasma Nε-(carboxymethyl)lysine and sRAGE levels are inversely associated with a number of metabolic syndrome risk factors in non-diabetic young-to-middle-aged medication-free subjects

• Published in: Clinical chemistry and laboratory medicine Vol. 52; no. 1; pp. 139 - 149
• Main Authors: Šebeková, Katarína, Krivošíková, Zora, Gajdoš, Martin
• Format: Journal Article
• Language: English
• Published: Germany De Gruyter 01.01.2014
• Subjects: (carboxymethyl)lysine (CML); Adolescent; Adult; Aged; central obesity; Cohort Studies; Female; Glycation End Products, Advanced - blood; healthy subjects; Humans; Lysine - analogs & derivatives; Lysine - blood; Male; metabolic syndrome; Metabolic Syndrome - blood; Metabolic Syndrome - etiology; Middle Aged; Receptor for Advanced Glycation End Products; Receptors, Immunologic - blood; Risk Factors; Serum Albumin - analysis; sRAGE; Young Adult

Interaction of advanced glycation end products (AGEs) with their specific cell-surface receptor for AGEs (RAGE) induces production of reactive oxygen species, pro-diabetic, pro-inflammatory, and pro-atherogenic responses. The metabolic syndrome (Metsy) imposes a high risk of development of cardiovas...