Excessive Mitochondrial Fission Suppresses Mucosal Repair by Impairing Butyrate Metabolism in Colonocytes

• Published in: Inflammatory bowel diseases Vol. 30; no. 1; pp. 114 - 124
• Main Authors: Fu, Shi-Chen, Qu, Jun-Yan, Li, Li-Xiang, Yang, Xiao-Xiao, Li, Yan-Qing, Zuo, Xiu-Li
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 05.01.2024
• Subjects: Animals; Antibiotics; Butyrates - metabolism; Butyrates - pharmacology; Colitis, Ulcerative - drug therapy; Enzymes; Humans; Inflammatory bowel disease; Intestinal Mucosa - metabolism; Metabolism; Mice; Mitochondrial Dynamics; Stem cells; ulcerative colitis; mitochondrial fission; mucosal healing; butyrate metabolism

Abstract Background Mucosal healing is one of the principal therapeutic targets for ulcerative colitis (UC). Mitochondria are dynamic organelles that undergo constant fusion and fission; however, the process that is most conducive to mucosal healing remains unclear. This study investigated the role...