Physical Activity and Sex Modulate Obesity Risk Linked to 3111T C Gene Variant of the CLOCK Gene in an Elderly Population: The SUN Project

• Published in: Chronobiology international Vol. 29; no. 10; pp. 1397 - 1404
• Main Authors: Galbete, Cecilia, Contreras, Rafael, Martínez, J. Alfredo, Martínez-González, Miguel Ángel, Guillén-Grima, Francisco, Marti, Amelia
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 01.12.2012; Taylor & Francis
• Subjects: Aged; Aged, 80 and over; Aging; Alleles; Body mass index; CLOCK; CLOCK Proteins - genetics; Cross-sectional study; Female; Gene Frequency - genetics; Genetic Predisposition to Disease; Genotype; Humans; Male; Middle Aged; Motor Activity - genetics; Mutation - genetics; Obesity - genetics; Obesity risk; Overweight - genetics; Polymorphism, Single Nucleotide - genetics; rs1801260; Sex Factors

Genetic factors may interact with physical activity levels to modify obesity risk. Our aim was to explore the influence of rs1801260 single-nucleotide polymorphism (SNP) (3111T C) of CLOCK gene on obesity risk, and to examine its potential interaction with lifestyle factors in an elderly population...