MYO5B and the Polygenic Landscape of Very Early-Onset Inflammatory Bowel Disease in an Ethnically Diverse Population

• Published in: Inflammatory bowel diseases Vol. 31; no. 1; pp. 189 - 199
• Main Authors: Watson, Ashleigh, Harris, R Alan, Engevik, Amy C, Oezguen, Numan, Nicholson, Maribeth R, Dooley, Sarah, Stubler, Rachel, Satter, Lisa Forbes, Karam, Lina B, Kellermayer, Richard
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 06.01.2025
• Subjects: Adolescent; Age of Onset; Child; Child, Preschool; Exome Sequencing; Female; Genetic Predisposition to Disease; Hispanic or Latino - genetics; Humans; Infant; Inflammatory bowel disease; Inflammatory Bowel Diseases - genetics; Male; Multifactorial Inheritance; Myosin Type V - genetics; Polymorphism, Single Nucleotide; ulcerative colitis; Crohn’s disease; pediatric

Abstract Background Genetic discovery in very early-onset inflammatory bowel disease (VEO-IBD) can elucidate not only the origins of VEO-IBD, but also later-onset inflammatory bowel disease. We aimed to investigate the polygenic origins of VEO-IBD in a cohort with a high proportion of Hispanic patie...