The effect of tizanidine on chronic vasospasm in rats

• Published in: Acta neurochirurgica Vol. 142; no. 9; pp. 1047 - 1054
• Main Authors: Berkman, M Z, Iplikçioğlu, A C, Berkman, M K, Erbengi, T, San, T, Sav, A
• Format: Journal Article
• Language: English
• Published: Austria Springer Nature B.V 01.01.2000
• Subjects: Adrenergic alpha-2 Receptor Agonists; Aneurysms; Animals; Chronic Disease; Clonidine - analogs & derivatives; Clonidine - pharmacology; Clonidine - therapeutic use; Disease Models, Animal; Femoral Artery - drug effects; Femoral Artery - pathology; Hemorrhage; Male; Muscle Relaxants, Central - pharmacology; Muscle Relaxants, Central - therapeutic use; Photomicrography; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage - complications; Vasospasm, Intracranial - etiology; Vasospasm, Intracranial - physiopathology; Vasospasm, Intracranial - prevention & control

Cerebral vasospasm after subarachnoid hemorrhage (SAH) has remained a major cause of morbidity and mortality in patients with SAH. Excitatory neurotransmitters are gathered in the extracellular space during ischemia due to cerebral vasospasm and initiate or stimulate a series of pathophysiological b...