Antibody Fingerprints Linking Adenoviral Anti-PF4 Disorders

• Published in: The New England journal of medicine Vol. 390; no. 19; pp. 1827 - 1829
• Main Authors: Wang, Jing Jing, Schönborn, Linda, Warkentin, Theodore E., Chataway, Tim, Grosse, Leonie, Simioni, Paolo, Moll, Stephan, Greinacher, Andreas, Gordon, Tom P.
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 16.05.2024
• Subjects: Ad26COVS1 - adverse effects; Ad26COVS1 - immunology; Adenoviridae; Adenovirus Infections, Human - complications; Adenovirus Infections, Human - immunology; Adenovirus Infections, Human - virology; Adenoviruses; Allergy; Amino acids; Antibodies; Antibodies, Viral - blood; Antigens; Autoantibodies - blood; Autoantibodies - immunology; Autoimmune Disease; Binding sites; ChAdOx1 nCoV-19 - adverse effects; ChAdOx1 nCoV-19 - immunology; Coagulation; Coronavirus; Coronaviruses; COVID-19 vaccines; Hematology; Humans; Immunization; Immunoglobulins; Immunology; Infections; Infectious Disease; Light; Oncology; Patients; Platelet Factor 4 - immunology; Purpura, Thrombocytopenic, Idiopathic - etiology; Purpura, Thrombocytopenic, Idiopathic - immunology; Thrombocytopenia; Thrombosis; Vaccines; Viral Infections

Antibody Link for VITT and VITT-like DisordersThe antibody that mediates the occurrence of VITT associated with adenoviral-based Covid-19 vaccines is nearly identical to the antibodies produced in response to natural adenoviral infection.