Prediction of gene expression using histone modification patterns extracted by Particle Swarm Optimization

• Published in: Bioinformatics (Oxford, England) Vol. 41; no. 2
• Main Authors: Paul, Niels Benjamin, Wolber, Jonas Chanrithy, Sahrhage, Malte Lennart, Beißbarth, Tim, Haubrock, Martin
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 04.02.2025
• Subjects: Algorithms; Computational Biology - methods; Gene Expression Regulation; Histone Code; Histones - genetics; Histones - metabolism; Humans; Machine Learning; Particle Swarm Optimization; Promoter Regions, Genetic; Protein Processing, Post-Translational

Motivation Histone modifications play an important role in transcription regulation. Although the general importance of some histone modifications for transcription regulation has been previously established, the relevance of others and their interaction is subject to ongoing research. By training M...