Expression of Apoptosis Markers in the Retinas of Human Subjects with Diabetes

• Published in: Investigative ophthalmology & visual science Vol. 45; no. 8; pp. 2760 - 2766
• Main Authors: El-Asrar, Ahmed M. Abu, Dralands, Lieve, Missotten, Luc, Al-Jadaan, Ibrahim A, Geboes, Karel
• Format: Journal Article
• Language: English
• Published: Rockville, MD ARVO 01.08.2004; Association for Research in Vision and Ophtalmology
• Subjects: Adult; Aged; Apoptosis; bcl-2-Associated X Protein; Biological and medical sciences; Biomarkers - analysis; Caspase 3; Caspases - metabolism; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - pathology; Diabetic Retinopathy - metabolism; Diabetic Retinopathy - pathology; Epistemology; Excavation and methods; Eye Proteins - metabolism; Fas Ligand Protein; fas Receptor - metabolism; Female; Field method; Glial Fibrillary Acidic Protein - metabolism; Humans; Immunoenzyme Techniques; Inhibitor of Apoptosis Proteins; Male; Medical sciences; Membrane Glycoproteins - metabolism; Methodology and general studies; Microtubule-Associated Proteins - metabolism; Middle Aged; Mitogen-Activated Protein Kinase 1 - metabolism; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases - metabolism; Neoplasm Proteins; Neuroglia - metabolism; Ophthalmology; Prehistory and protohistory; Proto-Oncogene Proteins - metabolism; Proto-Oncogene Proteins c-bcl-2 - metabolism; Retinopathies; Tumor Suppressor Protein p53 - metabolism; Endocrinopathy; Human; Disease; Diabetes mellitus; Retina; Method; Eye; Cell death; Pigments; Population; Ophthalmology; Technique; Apoptosis

To investigate the expression of the apoptotic mediators in the retinas from human subjects with diabetes mellitus. Ten donor eyes from five subjects with diabetes mellitus, and eight eyes from four nondiabetic subjects without known ocular disease serving as control subjects were examined. Immunohi...