Tackling the biophysical properties of sphingolipids to decipher their biological roles

From the most simple sphingoid bases to their complex glycosylated derivatives, several sphingolipid species were shown to have a role in fundamental cellular events and/or disease. Increasing evidence places lipid-lipid interactions and membrane structural alterations as central mechanisms underlyi...

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Published inBiological chemistry Vol. 396; no. 6; pp. 597 - 609
Main Authors Carreira, Ana C., Ventura, Ana E., Varela, Ana R.P., Silva, Liana C.
Format Journal Article
LanguageEnglish
Published Germany De Gruyter 01.06.2015
Subjects
Animals
ceramides
Ceramides - metabolism
glycosphingolipids
Glycosphingolipids - metabolism
Humans
lipid domains
membrane structural alterations
model membrane studies
Sphingolipids - metabolism
sphingosine
Sphingosine - metabolism
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Summary:From the most simple sphingoid bases to their complex glycosylated derivatives, several sphingolipid species were shown to have a role in fundamental cellular events and/or disease. Increasing evidence places lipid-lipid interactions and membrane structural alterations as central mechanisms underlying the action of these lipids. Understanding how these molecules exert their biological roles by studying their impact in the physical properties and organization of membranes is currently one of the main challenges in sphingolipid research. Herein, we review the progress in the state-of-the-art on the biophysical properties of sphingolipid-containing membranes, focusing on sphingosine, ceramides, and glycosphingolipids.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1431-6730
1437-4315
DOI:10.1515/hsz-2014-0283