Intensity of Statin Treatment in Korean Patients with Acute Myocardial Infarction and Very Low LDL Cholesterol
Data on the intensity of statin therapy for patients with acute myocardial infarction (MI) and very low baseline low-density lipoprotein (LDL) cholesterol level are lacking. We sought to assess the impact of statin intensity in patients with acute MI and LDL cholesterol <70 mg/dL. A total of 1,08...
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| Published in | Journal of lipid and atherosclerosis Vol. 8; no. 2; pp. 208 - 220 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Korea (South)
Korean Society of Lipidology and Atherosclerosis
01.09.2019
한국지질동맥경화학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2287-2892 2288-2561 |
| DOI | 10.12997/jla.2019.8.2.208 |
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| Abstract | Data on the intensity of statin therapy for patients with acute myocardial infarction (MI) and very low baseline low-density lipoprotein (LDL) cholesterol level are lacking. We sought to assess the impact of statin intensity in patients with acute MI and LDL cholesterol <70 mg/dL.
A total of 1,086 patients with acute MI and baseline LDL cholesterol <70 mg/dL from the Korea Acute Myocardial Infarction Registry-National Institute of Health database were divided into less intensive statin (expected LDL reduction <40%, n=302) and more intensive statin (expected LDL reduction ≥40%, n=784) groups. The primary endpoint was major adverse cardiac and cerebrovascular events (MACCEs), a composite of cardiac death, MI, revascularization occurring at least 30 days after admission, and stroke, at 12 months.
After 1:2 propensity matching, differences were not observed between less intensive (n=302) and more intensive statin (n=604) groups in incidence of cardiac death (0.3% vs. 0.3%) and hemorrhagic stroke (0.3% vs. 0.5%,
=0.727) at 12 months. Compared with the less intensive statin group, the more intensive statin group showed lower target-vessel revascularization (4.6% vs. 1.8%,
=0.027) and MACCE (11.6% vs. 7.0%,
=0.021). Major bleeding was not different between less intensive and more intensive statin groups (1.0% vs. 2.6%,
=0.118).
More intensive statin therapy was associated with significantly lower major adverse cardiovascular events in patients with acute MI and very low LDL cholesterol compared with less intensive statin therapy. |
|---|---|
| AbstractList | Data on the intensity of statin therapy for patients with acute myocardial infarction (MI) and very low baseline low-density lipoprotein (LDL) cholesterol level are lacking. We sought to assess the impact of statin intensity in patients with acute MI and LDL cholesterol <70 mg/dL.
A total of 1,086 patients with acute MI and baseline LDL cholesterol <70 mg/dL from the Korea Acute Myocardial Infarction Registry-National Institute of Health database were divided into less intensive statin (expected LDL reduction <40%, n=302) and more intensive statin (expected LDL reduction ≥40%, n=784) groups. The primary endpoint was major adverse cardiac and cerebrovascular events (MACCEs), a composite of cardiac death, MI, revascularization occurring at least 30 days after admission, and stroke, at 12 months.
After 1:2 propensity matching, differences were not observed between less intensive (n=302) and more intensive statin (n=604) groups in incidence of cardiac death (0.3% vs. 0.3%) and hemorrhagic stroke (0.3% vs. 0.5%,
=0.727) at 12 months. Compared with the less intensive statin group, the more intensive statin group showed lower target-vessel revascularization (4.6% vs. 1.8%,
=0.027) and MACCE (11.6% vs. 7.0%,
=0.021). Major bleeding was not different between less intensive and more intensive statin groups (1.0% vs. 2.6%,
=0.118).
More intensive statin therapy was associated with significantly lower major adverse cardiovascular events in patients with acute MI and very low LDL cholesterol compared with less intensive statin therapy. Data on the intensity of statin therapy for patients with acute myocardial infarction (MI) and very low baseline low-density lipoprotein (LDL) cholesterol level are lacking. We sought to assess the impact of statin intensity in patients with acute MI and LDL cholesterol <70 mg/dL.OBJECTIVEData on the intensity of statin therapy for patients with acute myocardial infarction (MI) and very low baseline low-density lipoprotein (LDL) cholesterol level are lacking. We sought to assess the impact of statin intensity in patients with acute MI and LDL cholesterol <70 mg/dL.A total of 1,086 patients with acute MI and baseline LDL cholesterol <70 mg/dL from the Korea Acute Myocardial Infarction Registry-National Institute of Health database were divided into less intensive statin (expected LDL reduction <40%, n=302) and more intensive statin (expected LDL reduction ≥40%, n=784) groups. The primary endpoint was major adverse cardiac and cerebrovascular events (MACCEs), a composite of cardiac death, MI, revascularization occurring at least 30 days after admission, and stroke, at 12 months.METHODSA total of 1,086 patients with acute MI and baseline LDL cholesterol <70 mg/dL from the Korea Acute Myocardial Infarction Registry-National Institute of Health database were divided into less intensive statin (expected LDL reduction <40%, n=302) and more intensive statin (expected LDL reduction ≥40%, n=784) groups. The primary endpoint was major adverse cardiac and cerebrovascular events (MACCEs), a composite of cardiac death, MI, revascularization occurring at least 30 days after admission, and stroke, at 12 months.After 1:2 propensity matching, differences were not observed between less intensive (n=302) and more intensive statin (n=604) groups in incidence of cardiac death (0.3% vs. 0.3%) and hemorrhagic stroke (0.3% vs. 0.5%, p=0.727) at 12 months. Compared with the less intensive statin group, the more intensive statin group showed lower target-vessel revascularization (4.6% vs. 1.8%, p=0.027) and MACCE (11.6% vs. 7.0%, p=0.021). Major bleeding was not different between less intensive and more intensive statin groups (1.0% vs. 2.6%, p=0.118).RESULTSAfter 1:2 propensity matching, differences were not observed between less intensive (n=302) and more intensive statin (n=604) groups in incidence of cardiac death (0.3% vs. 0.3%) and hemorrhagic stroke (0.3% vs. 0.5%, p=0.727) at 12 months. Compared with the less intensive statin group, the more intensive statin group showed lower target-vessel revascularization (4.6% vs. 1.8%, p=0.027) and MACCE (11.6% vs. 7.0%, p=0.021). Major bleeding was not different between less intensive and more intensive statin groups (1.0% vs. 2.6%, p=0.118).More intensive statin therapy was associated with significantly lower major adverse cardiovascular events in patients with acute MI and very low LDL cholesterol compared with less intensive statin therapy.CONCLUSIONMore intensive statin therapy was associated with significantly lower major adverse cardiovascular events in patients with acute MI and very low LDL cholesterol compared with less intensive statin therapy. Objective: Data on the intensity of statin therapy for patients with acute myocardial infarction (MI) and very low baseline low-density lipoprotein (LDL) cholesterol level are lacking. We sought to assess the impact of statin intensity in patients with acute MI and LDL cholesterol <70 mg/dL. Methods: A total of 1,086 patients with acute MI and baseline LDL cholesterol <70 mg/dL from the Korea Acute Myocardial Infarction Registry-National Institute of Health database were divided into less intensive statin (expected LDL reduction <40%, n=302) and more intensive statin (expected LDL reduction ≥40%, n=784) groups. The primary endpoint was major adverse cardiac and cerebrovascular events (MACCEs), a composite of cardiac death, MI, revascularization occurring at least 30 days after admission, and stroke, at 12 months. Results: After 1:2 propensity matching, differences were not observed between less intensive (n=302) and more intensive statin (n=604) groups in incidence of cardiac death (0.3% vs. 0.3%) and hemorrhagic stroke (0.3% vs. 0.5%, p=0.727) at 12 months. Compared with the less intensive statin group, the more intensive statin group showed lower target-vessel revascularization (4.6% vs. 1.8%, p=0.027) and MACCE (11.6% vs. 7.0%, p=0.021). Major bleeding was not different between less intensive and more intensive statin groups (1.0% vs. 2.6%, p=0.118). Conclusion: More intensive statin therapy was associated with significantly lower major adverse cardiovascular events in patients with acute MI and very low LDL cholesterol compared with less intensive statin therapy. KCI Citation Count: 1 |
| Author | Park, Jong Seon Rha, Seung Woon Yoon, Jung Han Choi, Dong Ju Kim, Hyo Soo Gwon, Hyeon Cheol Seung, Ki Bae Cha, Kwang Soo Seong, In Whan Hur, Seung Ho Cho, Myeong Chan Kim, Chong Jin Jeong, Myung Ho Joo, Seung Jae Sim, Doo Sun Kim, Doo Il Chae, Jei Keon Ahn, Tae Hoon Chae, Shung Chull Oh, Seok Kyu Hwang, Jin Yong |
| AuthorAffiliation | 15 Department of Cardiology, Chungnam National University Hospital, Daejeon, Korea 2 Department of Cardiology, Seoul National University Hospital, Seoul, Korea 9 Division of Cardiology, Yeungnam University Hospital, Daegu, Korea 19 Department of Cardiology, Gachon University Gil Medical Center, Incheon, Korea 10 Division of Cardiology, Yonsei University Wonju College of Medicine, Wonju Severance Christian Hospital, Wonju, Korea 11 Department of Cardiology, Chunbuk National University Hospital, Jeonju, Korea 5 The Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea 6 Department of Cardiology, Kyungpook National University Hospital, Daegu, Korea 8 Department of Cardiology, Pusan National University Hospital, Busan, Korea 12 Department of Cardiology, Jeju National University Hospital, Jeju, Korea 17 Department of Cardiology, Inje University Haeundae Paik Hospital, Busan, Korea 7 Department of Cardiology, Kyung Hee University Hospital at Gangdong, Seoul, Korea 18 Department of Cardiolo |
| AuthorAffiliation_xml | – name: 15 Department of Cardiology, Chungnam National University Hospital, Daejeon, Korea – name: 5 The Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea – name: 3 Department of Cardiology, Seoul Samsung Medical Center, Sungkyunkwan University, Seoul, Korea – name: 4 Department of Cardiology, The Catholic University of Korea, Seoul, Korea – name: 16 Department of Cardiology, Chungbuk National University Hospital, Cheongju, Korea – name: 2 Department of Cardiology, Seoul National University Hospital, Seoul, Korea – name: 20 Division of Cardiology, Gyungsang National University Hospital, Jinju, Korea – name: 7 Department of Cardiology, Kyung Hee University Hospital at Gangdong, Seoul, Korea – name: 14 Division of Cardiology, Keimyung University Dongsan Medical Center, Daegu, Korea – name: 8 Department of Cardiology, Pusan National University Hospital, Busan, Korea – name: 13 Department of Cardiology, Seoul National University Bundang Hospital, Seongnam, Korea – name: 19 Department of Cardiology, Gachon University Gil Medical Center, Incheon, Korea – name: 9 Division of Cardiology, Yeungnam University Hospital, Daegu, Korea – name: 17 Department of Cardiology, Inje University Haeundae Paik Hospital, Busan, Korea – name: 6 Department of Cardiology, Kyungpook National University Hospital, Daegu, Korea – name: 10 Division of Cardiology, Yonsei University Wonju College of Medicine, Wonju Severance Christian Hospital, Wonju, Korea – name: 1 Department of Cardiovascular Medicine, Chonnam National University Hospital, Gwangju, Korea – name: 11 Department of Cardiology, Chunbuk National University Hospital, Jeonju, Korea – name: 18 Department of Cardiology, Wonkwang University Hospital, Iksan, Korea – name: 12 Department of Cardiology, Jeju National University Hospital, Jeju, Korea |
| Author_xml | – sequence: 1 givenname: Doo Sun orcidid: 0000-0003-4162-7902 surname: Sim fullname: Sim, Doo Sun organization: Department of Cardiovascular Medicine, Chonnam National University Hospital, Gwangju, Korea – sequence: 2 givenname: Myung Ho orcidid: 0000-0003-4173-1494 surname: Jeong fullname: Jeong, Myung Ho organization: Department of Cardiovascular Medicine, Chonnam National University Hospital, Gwangju, Korea – sequence: 3 givenname: Hyo Soo orcidid: 0000-0003-2977-6323 surname: Kim fullname: Kim, Hyo Soo organization: Department of Cardiology, Seoul National University Hospital, Seoul, Korea – sequence: 4 givenname: Hyeon Cheol orcidid: 0000-0002-8967-4305 surname: Gwon fullname: Gwon, Hyeon Cheol organization: Department of Cardiology, Seoul Samsung Medical Center, Sungkyunkwan University, Seoul, Korea – sequence: 5 givenname: Ki Bae orcidid: 0000-0002-6255-7336 surname: Seung fullname: Seung, Ki Bae organization: Department of Cardiology, The Catholic University of Korea, Seoul, Korea – sequence: 6 givenname: Seung Woon orcidid: 0000-0001-9456-9852 surname: Rha fullname: Rha, Seung Woon organization: The Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea – sequence: 7 givenname: Shung Chull orcidid: 0000-0002-9871-6976 surname: Chae fullname: Chae, Shung Chull organization: Department of Cardiology, Kyungpook National University Hospital, Daegu, Korea – sequence: 8 givenname: Chong Jin orcidid: 0000-0002-7460-2835 surname: Kim fullname: Kim, Chong Jin organization: Department of Cardiology, Kyung Hee University Hospital at Gangdong, Seoul, Korea – sequence: 9 givenname: Kwang Soo orcidid: 0000-0001-7980-4578 surname: Cha fullname: Cha, Kwang Soo organization: Department of Cardiology, Pusan National University Hospital, Busan, Korea – sequence: 10 givenname: Jong Seon orcidid: 0000-0001-5242-2756 surname: Park fullname: Park, Jong Seon organization: Division of Cardiology, Yeungnam University Hospital, Daegu, Korea – sequence: 11 givenname: Jung Han surname: Yoon fullname: Yoon, Jung Han organization: Division of Cardiology, Yonsei University Wonju College of Medicine, Wonju Severance Christian Hospital, Wonju, Korea – sequence: 12 givenname: Jei Keon orcidid: 0000-0001-5783-7950 surname: Chae fullname: Chae, Jei Keon organization: Department of Cardiology, Chunbuk National University Hospital, Jeonju, Korea – sequence: 13 givenname: Seung Jae orcidid: 0000-0002-4322-0703 surname: Joo fullname: Joo, Seung Jae organization: Department of Cardiology, Jeju National University Hospital, Jeju, Korea – sequence: 14 givenname: Dong Ju orcidid: 0000-0003-0146-2189 surname: Choi fullname: Choi, Dong Ju organization: Department of Cardiology, Seoul National University Bundang Hospital, Seongnam, Korea – sequence: 15 givenname: Seung Ho orcidid: 0000-0002-3895-1915 surname: Hur fullname: Hur, Seung Ho organization: Division of Cardiology, Keimyung University Dongsan Medical Center, Daegu, Korea – sequence: 16 givenname: In Whan orcidid: 0000-0003-4628-0258 surname: Seong fullname: Seong, In Whan organization: Department of Cardiology, Chungnam National University Hospital, Daejeon, Korea – sequence: 17 givenname: Myeong Chan orcidid: 0000-0002-0047-0227 surname: Cho fullname: Cho, Myeong Chan organization: Department of Cardiology, Chungbuk National University Hospital, Cheongju, Korea – sequence: 18 givenname: Doo Il surname: Kim fullname: Kim, Doo Il organization: Department of Cardiology, Inje University Haeundae Paik Hospital, Busan, Korea – sequence: 19 givenname: Seok Kyu orcidid: 0000-0001-7545-0143 surname: Oh fullname: Oh, Seok Kyu organization: Department of Cardiology, Wonkwang University Hospital, Iksan, Korea – sequence: 20 givenname: Tae Hoon surname: Ahn fullname: Ahn, Tae Hoon organization: Department of Cardiology, Gachon University Gil Medical Center, Incheon, Korea – sequence: 21 givenname: Jin Yong orcidid: 0000-0002-9198-4564 surname: Hwang fullname: Hwang, Jin Yong organization: Division of Cardiology, Gyungsang National University Hospital, Jinju, Korea |
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| Copyright | Copyright © 2019 The Korean Society of Lipid and Atherosclerosis. Copyright © 2019 The Korean Society of Lipid and Atherosclerosis. 2019 The Korean Society of Lipid and Atherosclerosis |
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| Keywords | Myocardial infarction Cholesterol Statins |
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| Snippet | Data on the intensity of statin therapy for patients with acute myocardial infarction (MI) and very low baseline low-density lipoprotein (LDL) cholesterol... Objective: Data on the intensity of statin therapy for patients with acute myocardial infarction (MI) and very low baseline low-density lipoprotein (LDL)... |
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| Title | Intensity of Statin Treatment in Korean Patients with Acute Myocardial Infarction and Very Low LDL Cholesterol |
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