Serum levels of genomic DNA of α1(I) collagen are elevated in scleroderma patients

• Published in: Journal of dermatology Vol. 44; no. 8; pp. 927 - 931
• Main Authors: Sawamura, Soichiro, Jinnin, Masatoshi, Shimbara, Miki, Nakamura, Kayo, Kudo, Hideo, Inoue, Kuniko, Nakayama, Wakana, Kajihara, Ikko, Fukushima, Satoshi, Ihn, Hironobu
• Format: Journal Article
• Language: English
• Published: England 01.08.2017
• Subjects: Adult; Aged; Aged, 80 and over; Biomarkers - blood; Cicatrix - blood; Cicatrix - epidemiology; Cicatrix - etiology; Collagen; Collagen Type I - genetics; Collagen Type II - genetics; diagnostic marker; DNA - blood; DNA - isolation & purification; endothelial injury; Female; Humans; Male; Middle Aged; pitting scars; Prevalence; Real-Time Polymerase Chain Reaction; RNA - blood; RNA - isolation & purification; RNA, Messenger; Scleroderma, Systemic - blood; Scleroderma, Systemic - complications; Scleroderma, Systemic - diagnosis; Sensitivity and Specificity; Skin Ulcer - blood; Skin Ulcer - epidemiology; Skin Ulcer - etiology; systemic sclerosis; Young Adult; collagen; pitting scars; systemic sclerosis; diagnostic marker; endothelial injury
• ISSN: 0385-2407; 1346-8138; 1346-8138
• DOI: 10.1111/1346-8138.13838

Recent studies have indicated that various nucleic acids are present in human sera, and attracted attention for their potential as novel disease markers in many human diseases. In this study, we tried to evaluate the possibility that DNA and RNA of collagens exist in human sera, and determined wheth...