Cystathionine γ Lyase Sulfhydrates the RNA Binding Protein Human Antigen R to Preserve Endothelial Cell Function and Delay Atherogenesis

• Published in: Circulation (New York, N.Y.) Vol. 139; no. 1; pp. 101 - 114
• Main Authors: Bibli, Sofia-Iris, Hu, Jiong, Sigala, Fragiska, Wittig, Ilka, Heidler, Juliana, Zukunft, Sven, Tsilimigras, Diamantis I., Randriamboavonjy, Voahanginirina, Wittig, Janina, Kojonazarov, Baktybek, Schürmann, Christoph, Siragusa, Mauro, Siuda, Daniel, Luck, Bert, Abdel Malik, Randa, Filis, Konstantinos A., Zografos, George, Chen, Chen, Wang, Dao Wen, Pfeilschifter, Josef, Brandes, Ralf P., Szabo, Csaba, Papapetropoulos, Andreas, Fleming, Ingrid
• Format: Journal Article
• Language: English
• Published: by the American College of Cardiology Foundation and the American Heart Association, Inc 02.01.2019

BACKGROUND:Hydrogen sulfide (H2S), generated by cystathionine γ lyase (CSE), is an important endogenous regulator of vascular function. The aim of the present study was to investigate the control and consequences of CSE activity in endothelial cells under physiological and proatherogenic conditions....