Investigation of the Differences in the Pharmacokinetics of CYP2D6 Substrates, Desipramine, and Dextromethorphan in Healthy African Subjects Carrying the Allelic Variants CYP2D617 and CYP2D629, When Compared with Normal Metabolizers - Marasanapalle, Venugopal P; Masimirembwa, Collen; Sivasubramanian, Rama; Sayyed, Sarfaraz; Weinzierl-Hinum, Armin; Mehta, Dheeraj; Kapungu, Nyasha Nicole; Kanji, Comfort; Thelingwani, Roslyn; Zack, Julia (Journal of clinical pharmacology, 2024)
Keywords: Adult; Alleles; Antidepressive Agents, Tricyclic - blood; Antidepressive Agents, Tricyclic - pharmacokinetics; Area Under Curve; Black People - genetics; Cytochrome P-450 CYP2D6 - genetics; Cytochrome P-450 CYP2D6 - metabolism; Desipramine - blood; Desipramine - pharmacokinetics; Dextromethorphan - blood; Dextromethorphan - pharmacokinetics; Female; Genotype; Half-Life; Healthy Volunteers; Humans; Male; Middle Aged; Young Adult; pharmacokinetics; CYP2D6 polymorphism; pharmacogenetics; healthy African subjects