A narrative review of the role of Eph receptors in head and neck squamous cell carcinoma

• Published in: Oral diseases Vol. 30; no. 3; pp. 833 - 845
• Main Authors: Al‐Jamaei, Aisha A. H., Subramanyam, Ramadugula V., Helder, Marco N., Forouzanfar, Tymour, Meij, Erik H., Al‐Jamei, Sayida, Visscher, Jan G. A. M.
• Format: Journal Article
• Language: English
• Published: Denmark Wiley Subscription Services, Inc 01.04.2024
• Subjects: Clinical trials; Eph protein; Eph receptors; EphA2 protein; Ephrin-B2 - metabolism; expression; Head & neck cancer; head and neck cancer; Head and neck carcinoma; Head and Neck Neoplasms - metabolism; head and neck squamous cell carcinoma; Humans; Immunosuppression; Kinases; metastasis; Proteins; Radioresistance; Receptor, EphB4 - metabolism; Receptors, Eph Family - metabolism; Squamous cell carcinoma; Squamous Cell Carcinoma of Head and Neck - metabolism; targeted therapy; targeted therapy; expression; head and neck cancer; metastasis; Eph receptors; head and neck squamous cell carcinoma

Tyrosine kinase receptors (TKR) coordinate a variety of pathological processes in head and neck squamous cell carcinoma (HNSCC), and eventually play a role in patient outcomes. In this review, the role of Eph receptors in HNSCC progression and the possibility of targeting these receptors are illustr...