Pleural fluid biomarkers to predict response to pleurodesis or indwelling pleural catheter for malignant pleural effusion: still a long way to go

This letter summarizes the current literature on pleural fluid biomarkers that predict treatment response to chemical pleurodesis and indwelling pleural catheters in patients with malignant pleural effusion. We found evidence on pleural fluid biomarkers to be limited to a few small studies, where th...

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Published inRespiratory research Vol. 26; no. 1; pp. 1 - 5
Main Authors Fjaellegaard, Katrine, Ahmadzai, Sina, Porcel, José M., Mei, Federico, Shaw, Jane A., Bodtger, Uffe
Format Journal Article
LanguageEnglish
Published London BioMed Central Ltd 20.08.2025
BioMed Central
BMC
Subjects
Biological markers
Biomarkers
Care and treatment
Chemical pleurodesis
Correspondence
Dextrose
Glucose
Health aspects
Indwelling pleural catheter
Medical research
Medicine, Experimental
Patient outcomes
Physiological aspects
Pleura
Pleural effusion
Pleural effusions
Pleurodesis
Prognosis
Denmark
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Abstract This letter summarizes the current literature on pleural fluid biomarkers that predict treatment response to chemical pleurodesis and indwelling pleural catheters in patients with malignant pleural effusion. We found evidence on pleural fluid biomarkers to be limited to a few small studies, where the biomarkers prognostic value was not tested in separate validation cohorts. Although low pleural fluid LDH, high glucose, and high pH levels are associated with pleurodesis success, no clinically valuable biomarker has been identified. Hence, further research on the inflammatory processes of malignant pleural effusion and during definitive pleural procedures is needed, as well as proper testing of potential biomarkers in separate model derivation and validation cohorts. Keywords: Biomarkers, Pleural effusion, Chemical pleurodesis, Indwelling pleural catheter
AbstractList Abstract This letter summarizes the current literature on pleural fluid biomarkers that predict treatment response to chemical pleurodesis and indwelling pleural catheters in patients with malignant pleural effusion. We found evidence on pleural fluid biomarkers to be limited to a few small studies, where the biomarkers prognostic value was not tested in separate validation cohorts. Although low pleural fluid LDH, high glucose, and high pH levels are associated with pleurodesis success, no clinically valuable biomarker has been identified. Hence, further research on the inflammatory processes of malignant pleural effusion and during definitive pleural procedures is needed, as well as proper testing of potential biomarkers in separate model derivation and validation cohorts.
This letter summarizes the current literature on pleural fluid biomarkers that predict treatment response to chemical pleurodesis and indwelling pleural catheters in patients with malignant pleural effusion. We found evidence on pleural fluid biomarkers to be limited to a few small studies, where the biomarkers prognostic value was not tested in separate validation cohorts. Although low pleural fluid LDH, high glucose, and high pH levels are associated with pleurodesis success, no clinically valuable biomarker has been identified. Hence, further research on the inflammatory processes of malignant pleural effusion and during definitive pleural procedures is needed, as well as proper testing of potential biomarkers in separate model derivation and validation cohorts. Keywords: Biomarkers, Pleural effusion, Chemical pleurodesis, Indwelling pleural catheter
This letter summarizes the current literature on pleural fluid biomarkers that predict treatment response to chemical pleurodesis and indwelling pleural catheters in patients with malignant pleural effusion. We found evidence on pleural fluid biomarkers to be limited to a few small studies, where the biomarkers prognostic value was not tested in separate validation cohorts. Although low pleural fluid LDH, high glucose, and high pH levels are associated with pleurodesis success, no clinically valuable biomarker has been identified. Hence, further research on the inflammatory processes of malignant pleural effusion and during definitive pleural procedures is needed, as well as proper testing of potential biomarkers in separate model derivation and validation cohorts.
ArticleNumber 259
Audience Academic
Author Mei, Federico
Shaw, Jane A.
Bodtger, Uffe
Ahmadzai, Sina
Fjaellegaard, Katrine
Porcel, José M.
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Cites_doi 10.1080/17476348.2020.1746647
10.5507/bp.2015.005
10.1183/09031936.06.00097505
10.1089/jpm.2012.0521
10.1136/thoraxjnl-2014-205285
10.1016/j.lungcan.2019.09.003
10.1097/LBR.0000000000000632
10.3310/hta24260
10.1016/S2213-2600(18)30288-1
10.1183/13993003.00349-2018
10.1016/j.jtho.2021.01.1616
10.1002/14651858.CD010529.pub2
10.1136/thorax-2022-219371
10.1097/LBR.0000000000000022
10.1016/j.ejcdt.2015.05.003
10.1056/nejmoa1716883
10.1016/j.lungcan.2008.02.017
10.9778/cmajo.20170163
10.1097/MCP.0000000000001125
10.1016/j.ejcdt.2014.08.005
10.1097/LBR.0000000000000602
10.1186/s12885-016-2529-1
10.1136/thorax-2022-219784
10.1016/j.lungcan.2012.03.006
10.1111/eci.12895
10.5507/bp.2014.038
10.1007/s00408-007-9042-x
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References S Shojaee (3288_CR28) 2013; 20
ME Roberts (3288_CR5) 2023; 78
R Asciak (3288_CR6) 2023; 78
CE Hooper (3288_CR22) 2012; 77
R Bhatnagar (3288_CR4) 2020; 24
H Yildirim (3288_CR19) 2007; 185
3288_CR10
M Lapidot (3288_CR18) 2013; 16
3288_CR30
AO Clive (3288_CR2) 2014; 69
R Bhatnagar (3288_CR7) 2018; 378
3288_CR14
M Hassan (3288_CR13) 2019; 137
H Yildirim (3288_CR20) 2008; 62
3288_CR3
S Alsayed (3288_CR11) 2015; 64
P Habal (3288_CR16) 2015; 159
SM Shehata (3288_CR12) 2015; 64
3288_CR1
M Hassan (3288_CR9) 2020; 14
G Ak (3288_CR15) 2009; 57
LH Hsu (3288_CR21) 2016; 16
P Habal (3288_CR23) 2015; 159
FS Ou (3288_CR29) 2021; 16
3288_CR24
JM Porcel (3288_CR26) 2020; 27
HB Grosu (3288_CR27) 2020; 27
S Muruganandan (3288_CR8) 2018; 6
K Psathakis (3288_CR17) 2006; 27
P Li (3288_CR25) 2018; 6
References_xml – volume: 14
  start-page: 645
  issue: 6
  year: 2020
  ident: 3288_CR9
  publication-title: Expert Rev Respir Med
  doi: 10.1080/17476348.2020.1746647
– volume: 159
  start-page: 576
  issue: 4
  year: 2015
  ident: 3288_CR23
  publication-title: Biomedical Papers
  doi: 10.5507/bp.2015.005
– volume: 27
  start-page: 817
  issue: 4
  year: 2006
  ident: 3288_CR17
  publication-title: Eur Respir J
  doi: 10.1183/09031936.06.00097505
– volume: 16
  start-page: 337
  issue: 4
  year: 2013
  ident: 3288_CR18
  publication-title: J Palliat Med
  doi: 10.1089/jpm.2012.0521
– volume: 57
  start-page: 22
  issue: 1
  year: 2009
  ident: 3288_CR15
  publication-title: Tuberk Toraks
– volume: 69
  start-page: 1098
  issue: 12
  year: 2014
  ident: 3288_CR2
  publication-title: Thorax
  doi: 10.1136/thoraxjnl-2014-205285
– volume: 137
  start-page: 14
  year: 2019
  ident: 3288_CR13
  publication-title: Lung Cancer
  doi: 10.1016/j.lungcan.2019.09.003
– volume: 27
  start-page: 86
  issue: 2
  year: 2020
  ident: 3288_CR26
  publication-title: J Bronchol Interv Pulmonol
  doi: 10.1097/LBR.0000000000000632
– volume: 24
  start-page: 1
  issue: 26
  year: 2020
  ident: 3288_CR4
  publication-title: Health Technol Assess (Rockv)
  doi: 10.3310/hta24260
– volume: 6
  start-page: 671
  issue: 9
  year: 2018
  ident: 3288_CR8
  publication-title: Lancet Respir Med
  doi: 10.1016/S2213-2600(18)30288-1
– ident: 3288_CR3
  doi: 10.1183/13993003.00349-2018
– volume: 16
  start-page: 537
  issue: 4
  year: 2021
  ident: 3288_CR29
  publication-title: J Thorac Oncol
  doi: 10.1016/j.jtho.2021.01.1616
– ident: 3288_CR1
  doi: 10.1002/14651858.CD010529.pub2
– volume: 78
  start-page: s43
  issue: Suppl 3
  year: 2023
  ident: 3288_CR6
  publication-title: Thorax
  doi: 10.1136/thorax-2022-219371
– ident: 3288_CR10
– volume: 20
  start-page: 304
  issue: 4
  year: 2013
  ident: 3288_CR28
  publication-title: J Bronchol Interv Pulmonol
  doi: 10.1097/LBR.0000000000000022
– volume: 64
  start-page: 593
  issue: 3
  year: 2015
  ident: 3288_CR12
  publication-title: Egypt J Chest Dis Tuberculosis
  doi: 10.1016/j.ejcdt.2015.05.003
– volume: 378
  start-page: 1313
  issue: 14
  year: 2018
  ident: 3288_CR7
  publication-title: N Engl J Med
  doi: 10.1056/nejmoa1716883
– ident: 3288_CR14
– volume: 62
  start-page: 139
  issue: 1
  year: 2008
  ident: 3288_CR20
  publication-title: Lung Cancer
  doi: 10.1016/j.lungcan.2008.02.017
– volume: 6
  start-page: E235
  issue: 2
  year: 2018
  ident: 3288_CR25
  publication-title: CMAJ Open
  doi: 10.9778/cmajo.20170163
– ident: 3288_CR30
  doi: 10.1097/MCP.0000000000001125
– volume: 64
  start-page: 153
  issue: 1
  year: 2015
  ident: 3288_CR11
  publication-title: Egypt J Chest Dis Tuberculosis
  doi: 10.1016/j.ejcdt.2014.08.005
– volume: 27
  start-page: 4
  issue: 1
  year: 2020
  ident: 3288_CR27
  publication-title: J Bronchol Interv Pulmonol
  doi: 10.1097/LBR.0000000000000602
– volume: 16
  start-page: 463
  year: 2016
  ident: 3288_CR21
  publication-title: BMC Cancer
  doi: 10.1186/s12885-016-2529-1
– volume: 78
  start-page: s1
  issue: Suppl 3
  year: 2023
  ident: 3288_CR5
  publication-title: Thorax
  doi: 10.1136/thorax-2022-219784
– volume: 77
  start-page: 443
  issue: 2
  year: 2012
  ident: 3288_CR22
  publication-title: Lung Cancer
  doi: 10.1016/j.lungcan.2012.03.006
– ident: 3288_CR24
  doi: 10.1111/eci.12895
– volume: 159
  start-page: 234
  issue: 2
  year: 2015
  ident: 3288_CR16
  publication-title: Biomedical Papers
  doi: 10.5507/bp.2014.038
– volume: 185
  start-page: 349
  issue: 6
  year: 2007
  ident: 3288_CR19
  publication-title: Lung
  doi: 10.1007/s00408-007-9042-x
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Snippet This letter summarizes the current literature on pleural fluid biomarkers that predict treatment response to chemical pleurodesis and indwelling pleural...
Abstract This letter summarizes the current literature on pleural fluid biomarkers that predict treatment response to chemical pleurodesis and indwelling...
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StartPage 1
SubjectTerms Biological markers
Biomarkers
Care and treatment
Chemical pleurodesis
Correspondence
Dextrose
Glucose
Health aspects
Indwelling pleural catheter
Medical research
Medicine, Experimental
Patient outcomes
Physiological aspects
Pleura
Pleural effusion
Pleural effusions
Pleurodesis
Prognosis
Title Pleural fluid biomarkers to predict response to pleurodesis or indwelling pleural catheter for malignant pleural effusion: still a long way to go
URI https://pubmed.ncbi.nlm.nih.gov/PMC12366042
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