Pregnancy induces longitudinal changes in urinary C‐peptide creatinine ratio in women with type 1 diabetes

• Published in: Diabetic medicine Vol. 41; no. 1; pp. e15154 - n/a
• Main Authors: Mendoza, Lilian C., Tashkova, Martina, Corcoy, Rosa, Dornhorst, Anne
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.01.2024
• Subjects: C-Peptide - urine; Creatinine; Creatinine - urine; C‐peptide; Diabetes; Diabetes mellitus (insulin dependent); Diabetes Mellitus, Type 1; Family; Female; Humans; Longitudinal Studies; Peptides; Postpartum; Pregnancy; type 1 diabetes; urinary C‐peptide creatinine ratio; Womens health; type 1 diabetes; urinary C-peptide creatinine ratio; C-peptide; pregnancy
• ISSN: 0742-3071; 1464-5491
• DOI: 10.1111/dme.15154

Aims Changes in maternal serum C‐peptide have been described during pregnancy in women with Type 1 diabetes. We aimed to determine whether in these women, C‐peptide, as measured by the urinary C‐peptide creatinine ratio (UCPCR), display changes during the course of pregnancy and in the postpartum period. Methods In this longitudinal study including 26 women, UCPCR was measured in the first, second, and third trimester of pregnancy, and postpartum, using a high sensitivity two‐step chemiluminescent microparticle immunoassay. Results UCPCR was detectable in 7/26 (26.9%) participants in the first trimester, 10/26 (38.4%) in the second trimester, and 18/26 (69.2%) in the third trimester. Changes in UCPCR concentrations were observed throughout pregnancy, significantly increasing from first to third trimester. UCPCR concentration in the three trimesters was associated with a shorter duration of diabetes and in the third trimester also with first trimester UCPCR. Conclusion UCPCR detects longitudinal changes during pregnancy in women with type 1 diabetes mellitus, more marked in those with shorter diabetes duration.